Cervical cancer stem cells selectively overexpress HPV oncoprotein E6 that controls stemness and self renewal through upregulation of HES1.

CONCLUSIONS: Our findings suggest the possible mechanism by which HPVE6 potentially regulate and maintain stem-like cancer cells through Hes1.
PMID: 26988248 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - March 17, 2016 Category: Cancer & Oncology Authors: Das BC, Tyagi A, Vishnoi K, Mahata S, Verma G, Srivastava Y, Masaldan S, Roy BG, Bharti AC Tags: Clin Cancer Res Source Type: research