Cytotoxic effects of nickel nanowires in human fibroblasts

Publication date: Available online 9 March 2016 Source:Toxicology Reports Author(s): Laura P. Felix, Jose E. Perez, Maria F. Contreras, Timothy Ravasi, Jürgen Kosel The increasing interest in the use of magnetic nanostructures for biomedical applications necessitates rigorous studies to be carried out in order to determine their potential toxicity. This work attempts to elucidate the cytotoxic effects of nickel nanowires (NWs) in human fibroblasts WI-38 by a colorimetric assay (MTT) under two different parameters: NW concentration and exposure time. This was complemented with TEM and confocal images to assess the NWs internalization and to identify any changes in the cell morphology. Ni NWs were fabricated by electrodeposition using porous alumina templates. Energy dispersive X-Ray analysis, scanning electron microscopy and transmission electron microscopy imaging were used for NW characterization. The results showed decreased cell metabolic activity for incubation times longer than 24hours and no negative effects for exposure times shorter than that. The cytotoxicity effects for human fibroblasts were then compared with those reported for HCT 116 cells, and the findings point out that it is relevant to consider the cellular size. In addition, the present study compares the toxic effects of equivalent amounts of nickel in the form of its salt to those of NWs and shows that the NWs are more toxic than the salts. Internalized NWs were found in vesicles inside of the...
Source: Toxicology Reports - Category: Toxicology Source Type: research

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Publication date: Available online 21 September 2019Source: Materials Today: ProceedingsAuthor(s): Nagendra Kumar Maurya, Manish Maurya, Ashish Kumar Srivastava, Shashi Prakash Dwivedi, Abdhesh kumar, Sandeep ChauhanAbstractThis experimental investigation deals with the effect of SiC content on aluminium alloy Al 6061. Composites were fabricated with varied (0, 1, 2, 3 and 5) weight percent of SiC content via stir casting method. Scanning electronic microscope test had confirmed the uniform distribution of reinforced particles. It was seen that the density of Al 6061/SiC composite was improved with the reinforcement of SiC...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: Available online 21 September 2019Source: The Annals of Thoracic SurgeryAuthor(s): Chien-Hung Chiu, Peng Zhang, Andrew C. Chang, Brian A. Derstine, Brian E. Ross, Binu Enchakalody, Nidhi V. Shah, Stewart C. Wang, Yin-Kai Chao, Jules LinAbstractBackgroundIn patients undergoing neoadjuvant chemoradiotherapy (nCRT) followed by surgery for locally advanced esophageal squamous cell carcinoma (ESCC), patients with a pathological complete response (pCR) have the greatest benefit. The purpose of this study was to identify morphomic factors obtained from pre-treatment computed tomography scans associated with a pa...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
In conclusion, evaluation of the present method showed that the newly developed multiplex qPCR is highly specific, precise, and robust method that has potential for application in food-testing laboratories.Graphical abstract
Source: Food Research International - Category: Food Science Source Type: research
Discussion Pulmonary embolism (PE) is potentially life-threatening but fortunately rare event especially in the pediatric population. It was first described in children in 1861. PE is likely underreported because of minimal or non-specific clinical symptoms. The incidence is estimated at 0.05-4.2% with the 4.2% based on autopsy reports. It is probably also increasing as more central venous catheters (CVC) are used, and more children are surviving previously poor prognostic diseases. There is a bimodal distribution with cases
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
We report a case of invasive mucormycosis in 52 year-old woman. CT-scan and magnetic resonance imaging found a partial right sinus thrombosis associated with homolateral ethmoidal and maxillary sinusitis with submucosal inflammation. Histopathological examination of excised tissue was positive for mucormycosis. Our patient was treated by surgical debridement and a combination of amphotericin B and caspofungin, with a good outcome.
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
Publication date: 25 January 2020Source: Journal of Alloys and Compounds, Volume 814Author(s): Thirupathi Gadipelly, Arup Dasgupta, Chanchal Ghosh, Vaishnavi Krupa, D. Sornadurai, Binaya Kumar Sahu, Sandip DharaAbstractIn the present work, we established an ex-situ procedure to synthesize Y2Ti2O7 nanopowder using the microwave-hydrothermal technique followed by conventional calcination treatment. This powder is otherwise synthesized by in-situ through a reaction between Y2O3 and Ti in a steel matrix for the production of oxide dispersion strengthened (ODS) steels. The hydrothermal synthesis was involved of chemical reactio...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
Publication date: Available online 21 September 2019Source: European Polymer JournalAuthor(s): Tatiya Trongsatitkul, Clara Jiménez-Saelices, Bruno Pontoire, Isabelle Capron, Denis LourdinAbstractStarch films containing eicosane droplets with diameters of 3-5 μm homogeneously distributed over the thickness were prepared using the casting method. The films also contain a quantity of water (4 to 22%) depending on the relative humidity during conditioning (from 7% to 90%, respectively). The calorimetric behavior of dispersed eicosane droplets, studied by Differential Scanning Calorimetry, shows a shift in the melting...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Authors: Fishman JE, Kim GJ, Kyeong NY, Goldin JG, Glassberg MK Abstract OBJECTIVE: Our purpose was to compare quantitative CT-derived changes in lung fibrosis with pulmonary function, including DLCO, in human subjects with idiopathic pulmonary fibrosis who received an injection of one of two different intravenous doses of human bone-marrow-derived mesenchymal stem cells. PATIENTS AND METHODS: Two three-subject cohorts from the AETHER trial (Allogeneic Human Cells in subjects with Idiopathic Pulmonary Fibrosis via Intravenous Delivery) underwent high-resolution CT and clinical testing at baseline, 24 weeks, and...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSION: Our findings suggest that although MCI subjects showed similar behavioral phenotypes at the time of diagnosis, EF and further progression were associated with different brain regions according to Aβ burden. Clarification of the etiologies and nature of EF impairment in aMCI are critical for disease prognosis and management. PMID: 31538428 [PubMed - in process]
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
Publication date: Available online 21 September 2019Source: Materials Science and Engineering: AAuthor(s): S. Daryadel, A. Behroozfar, M. Minary-JolandanAbstractIn situ nanomechanics in scanning electron microscope (SEM) and transmission electron microscope (TEM) has been the gold-standard for direct observation of deformation mechanisms of metals and alloys. The extracted deformation mechanisms complement the process – microstructure – property relationship that is required for the full understanding of the mechanical behavior of these materials. Micro-pillar compression is perhaps the most frequently used met...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
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