Screening for gastric cancer in Western countries

Gastric cancer is the fifth most common cancer and third leading cause of cancer-related death worldwide.1 In 2013, 841 000 people worldwide died due to gastric cancer.2 Eastern Asia, Eastern Europe and some regions in Central and South America have the highest incidence of stomach cancer, whereas Western Europe and North America have lower rates. The majority of gastric malignancies are intestinal type adenocarcinomas.3 These cancers develop according to a multistep process, in strong association with Helicobacter pylori infection. This bacterium causes chronic gastritis, which can slowly progress via atrophy, intestinal metaplasia and dysplasia to gastric adenocarcinoma.4 This process takes decades3 and provides an excellent window of opportunity for early detection and prevention of gastric cancer. Several strategies have been proposed for gastric cancer screening. These include H. pylori screening and treatment, endoscopy with random or targeted biopsy sampling, serological...
Source: Gut - Category: Gastroenterology Authors: Tags: Commentary Source Type: research

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This study aimed to investigate the correlation between the four OMP genes (babA,oipA,sabA, andhomB) and gastroduodenal diseases. One hundred and seventy-sevenH. pylori strains were isolated from Chinese patients with different gastroduodenal diseases (49 chronic gastritis, 19 gastric ulcer, 33 gastric cancer, and 76 duodenal ulcer), 94 of which contained pathological information (41 superficial gastritis, 24 intestinal hyperplasia, and 29 gastric adenocarcinoma). The full-length amplification ofbabA,oipA,sabA,and homB genes was acquired and sequenced. Then, the genetic polymorphism was analyzed to compare with the referen...
Source: Medical Microbiology and Immunology - Category: Microbiology Source Type: research
ConclusionA2143G mutation is the most frequent mutation among clarithromycin resistant genes in Iran. Also, missense and frameshift mutations are frequent inrdxA andfrxA genes. Screening for these mutations could help researchers to investigate the most effective anti-H. pylori antibiotics and to prevent antibiotic resistance.
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
Conclusions. In this population with high rates of gastric cancer, we found that just over half of the H. pylori contained an intact cagPAI and 40 % had the vacA s1/i1/m1 genotype. Infection with these strains was associated with a more severe gastropathy. PMID: 32011229 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
This study aimed to examine the association betweenH. pylori and RELM β expression in gastric carcinoma and precursor lesions.H. pylori infection and RELM β expression were immunohistochemically evaluated in gastric biopsies from 230 patients. The biopsies consisted of normal gastric mucosa (n=20), mucosa with chronic gastritis (n=41), intestinal metaplasia (n=42), dysplasia (n=31), intestinal-type adenocarcinoma (n=56), and diffuse-type adenocarcinoma (n=40). RELM β expression was measured in gastric biopsies afterH. pylori eradication therapy in a subgroup of 32 patients. Cultured gastric cancer cell line ...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - Category: Research Source Type: research
Forty-five years have passed since Correa et  al1 proposed their hypothesis on the histopathological cascade leading to gastric adenocarcinoma claiming that gastric cancer usually resulted from chronic gastritis, subsequently leading to gland loss or atrophy, intestinal metaplasia, dysplasia, and eventually invasive cancer. The most common ri sk factor for gastritis soon revealed to be the colonization with Helicobacter pylori.2 Most infections occur during childhood and remain for life. They are almost invariably associated with chronic gastritis, which may eventually lead to a loss of mucosal glands.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Mentoring, Education, and Training Corner Source Type: research
Gastric cancer (GC) begins development in the mucus-producing cells which line the stomach [1]. Approximately 90 to 95% of all GCs are adenocarcinoma [6]. Since the middle of the 20th century, the incidence and mortality rates of GC in high-income countries of Europe and North America have been declining [13]. While there are many risk factors for the development of gastric cancer, such as Helicobacter pylori infection, chronic gastritis, pernicious anemia, intestinal metaplasia, gastric polyps, smoking, or having a family history of GC [11], obesity has not been named a risk.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
Helicobacter pylori-induced gastritis is the strongest risk factor for gastric adenocarcinoma, a malignancy preceded by a series of well-defined histological stages, including metaplasia. One microbial constituent that augments cancer risk is the cag type 4 secretion system (T4SS), which translocates the oncoprotein CagA into host cells. Aberrant stem cell activation...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
AbstractDespite being one of the most studied cancer-related infections, the relationship betweenHelicobacter pylori infection and gastric adenocarcinoma (GC) remains, in some points, obscure. Based on a critical analysis of the available literature regarding stomach microbiota, we aimed to shed light to a possible new interpretation of the current understanding about theHelicobacter pylori-related GC carcinogenesis. We analyzed data from the literature onHelicobacter pylori and other potential carcinogenic pathogens, in both benignant conditions and gastric adenocarcinoma.Helicobacter pylori is the dominant microorganism ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Conventional teaching is that Helicobacter pylori (HP) infection is required for the development of non-cardia gastric adenocarcinoma (NCGC) through a sequence of atrophic gastritis, intestinal metaplasia, dysplasia, and finally, cancer.1 –3 However, studies have not demonstrated a 100% rate of HP infection in gastric malignancy, hypothesized to be due to false negatives, gastric atrophy leading to apparent loss of infection, and inclusion of cardia, non-intestinal cancers.1–3
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Research Correspondence Source Type: research
This study shows the reverse association ofH. pyloricagPAI genotypes (cagH+ andcagG+) with the risk of CGA in male patients aged  ≥ 55 in Iran. Moreover, presence of thevacAc2 genotype in combination withcagPAI genotypes showed strong inverse associations with the risk of CGA and non ‐CGA. These findings may reveal a coordinated relationship between thevacA c2 andcagPAI genotypes. AbstractIran is a high ‐risk country for cardia gastric adenocarcinoma (CGA) in Central Asia, with an incidence rate five times the average global rate, and shows a high infection rate forHelicobacter pylori (69%). The aim w...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
More News: Adenocarcinoma | Cancer | Cancer & Oncology | Endoscopy | Gastric (Stomach) Cancer | Gastritis | Gastroenterology | Helicobacter Pylori | Lower Endoscopy