Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation

Conclusions Together, our observations indicate a sex-based and estrous cycle-dependent differential lung inflammatory response to O3 and involvement of two converging JAK2/STAT3 and AKT1/NF-κB pathways. To our knowledge, this is the first study specifically addressing the impact of the estrous cycle in O3-associated lung inflammatory pathways.

http://link.springer.com/10.1186/s13293-016-0069-7

Source: Biology of Sex Differences - March 5, 2016 Category: Biology Source Type: research

More News: Biology | Genetics | Respiratory Medicine | Study | Women