A novel synthetic novobiocin analog, FM-Nov17, induces DNA damage in CML cells through generation of reactive oxygen species.

CONCLUSIONS: FM-Nov17-induces DNA damage and mitochondria-dependent cellular apoptosis in CML cells. The process is mediated by the generation of ROS.
PMID: 26922548 [PubMed - as supplied by publisher]

Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Zhang N, Huang L, Tian J, Chen X, Ke F, Zheng M, Xu J, Wu L Tags: Pharmacol Rep Source Type: research