Abstract: The neonatal period represents a time of rapid growth and development. As a consequence, significant pharmacokinetic and pharmacodynamic changes occur. In addition, size, age, physiological changes, pathological processes and genomics all contribute to between patient variability that should be considered when trying to predict the action and disposition of drugs in the neonate. The problem is compounded by a relative paucity of research and data on many aspects of neonatal pharmacology. These issues pose significant challenges to the clinician to deliver safe and effective drug therapy to these vulnerable patients. Recent developments have attempted to redress this balance; many steps have been taken to increase the number of paediatric drug research programs and the traditional challenges to research in children and neonates are being addressed by legislative authorities, pharmaceutical companies, clinicians and the academic community. These research issues are discussed along with the basic science of neonatal pharmacology and new developments in the past few years.
Authors: Zhou ZG, Liu R, Tan HL, Ji XY, Yi XL, Song JF Abstract OBJECTIVE: The paper aims to explore the application of dexmedetomidine combined with dezocine in thoracoscopic radical resection of lung cancer and its effect on the awakening quality. PATIENTS AND METHODS: 122 patients undergoing thoracoscopic radical resection of lung cancer in The Affiliated Hospital of Qingdao University from April 2009 to January 2012 were selected as the subjects of the study. Among them, 68 patients were anesthetized with dexmedetomidine combined with dezocine as a study group, 54 patients with midazolam combined with fenta...
Authors: Rosa F, Tortorelli AP, Quero G, Galiandro F, Fiorillo C, Sollazzi L, Alfieri S Abstract OBJECTIVE: The aim of this study was to investigate the impact of the preoperative American Society of Anesthesiologists-Physical status (ASA-PS) on both the short-term and long-term outcomes in patients with Gastric Cancer (GC). PATIENTS AND METHODS: In a retrospective observational study, a total of 473 GC patients were divided into the following 3 groups: ASA 1, ASA 2, and ASA 3-4. RESULTS: The ASA 3-4 group included significantly older patients compared to the other groups (p
Publication date: Available online 21 September 2019Source: Anesthesiology ClinicsAuthor(s): Kirolos A. Jacob, David E. Leaf
I was a scribe in a community ED for one year before matriculating to an osteopathic medical school. So far during my third year, I've been thinking a lot more about longevity in a few different specialties that interest me, namely emergency medicine, anesthesiology, and perhaps even neurology. As it stands, based off my own reading of this thread, reddit, and other sources, it seems that burnout is more prevalent in EM than perhaps any other specialty outside of general surgery. It has me... How do you avoid burnout? - M3 interested in EM, but wary about longevity &toll of the unpleasant aspects
Authors: Prud'homme C, Deschamps F, Moulin B, Hakime A, Al-Ahmar M, Moalla S, Roux C, Teriitehau C, de Baere T, Tselikas L Abstract Purpose: To review the available options of percutaneous ablation of lung metastasis. Methods: General indications, prognostic factors, and image guidance of percutaneous lung ablations were reviewed. Specificities, technical aspects, advantages and limitations of each technic were highlighted. Complications and follow up where also reviewed. Results: Image-guided, percutaneous ablation is of interest for patients with a limit number (
Authors: Lacroix SP, Malaise PR, Degey SV, Deflandre EP Abstract Prilocaine is widely used for spinal anesthesia. Its intermediate effect makes it a valuable choice for one-day surgery. The duration of the motor blockade (DMB) may have an impact on the length of stay. The goal of this study was to establish a correlation between the DMB and different parameters (hyperbaric prilocaine dose, puncture level, surgical position, age, patient weight, and patient height). We prospectively enrolled adult patients scheduled for ambulatory surgery (n = 384). Univariate and multivariate regressions (backward stepwise) were ap...
This systematic review compared the anesthetic efficacy between Gow-Gates (GG), Vazirani-Akinosi (VA), and mental incisive (MI) nerve blocks (NBs) with inferior alveolar nerve blocks (IANBs) in mandibular teeth with irreversible pulpitis using meta-analysis and trial sequential analysis (TSA).
J. Buggy Breast cancer recurs in 20% of patients following intended curative resection. In vitro data indicates that amide local anaesthetics, including lidocaine, inhibit cancer cell metastasis by inhibiting the tyrosine kinase enzyme Src. In a murine breast cancer surgery model, systemic lidocaine reduces postoperative pulmonary metastases. We investigated whether the additional administration of bosutinib (a known Src inhibitor) influences lidocaine’s observed beneficial effect in this in vivo model. Female BALB/c mice (n = 95) were inoculated with 25,000 4T1 cells into the mammary fad pad and after 7 day...
In conclusion, the new mild WI protocol is a superior experimental model to study the pathophysiological effects of elevated ICP induced by water intoxication. PMID: 31534063 [PubMed - as supplied by publisher]
Ive searched for advice on personal statements and I found a personal statement readers for pre-medical. Is there a list of people willing to read personal statements for ERAS or is there anyone here that would be willing to read my personal statement? I know its a little late to ask about this, but I had some personal issues come up that delayed my ability to finish the statement.