Molecular, Cellular and Functional Events in Axonal Sprouting after Stroke.

Molecular, Cellular and Functional Events in Axonal Sprouting after Stroke.
Exp Neurol. 2016 Feb 10;
Authors: Carmichael ST, Kathirvelu B, Schweppe CA, Nie EH
Abstract
Stroke is the leading cause of adult disability. Yet there is a limited degree of recovery in this disease. One of the mechanisms of recovery is the formation of new connections in the brain and spinal cord after stroke: post-stroke axonal sprouting. Studies indicate that post-stroke axonal sprouting occurs in mice, rats, primates and humans. Inducing post-stroke axonal sprouting in specific connections enhances recovery; blocking axonal sprouting impairs recovery. Behavioral activity patterns after stroke modify the axonal sprouting response. A unique regenerative molecular program mediates this aspect of tissue repair in the CNS. The types of connections that are formed after stroke indicate three patterns of axonal sprouting after stroke: Reactive, Reparative and Unbounded Axonal Sprouting. These differ in mechanism, location, relationship to behavioral recovery and, importantly, in their prospect for therapeutic manipulation to enhance tissue repair.
PMID: 26874223 [PubMed - as supplied by publisher]

Source: Experimental Neurology - February 10, 2016 Category: Neurology Authors: Carmichael ST, Kathirvelu B, Schweppe CA, Nie EH Tags: Exp Neurol Source Type: research