Regulation of Amino Acid Transporter Trafficking by mTORC1 in Primary Human Trophoblast cells is Mediated by the Ubiquitin Ligase Nedd4-2.

In conclusion, we have identified a novel link between mTORC1 signaling and ubiquitination, a common posttranslational modification. Because placental mTORC1 is inhibited in fetal growth restriction and activated in fetal overgrowth, we propose that regulation of placental amino acid transporter ubiquitination by mTORC1 and Nedd4-2 constitutes a molecular mechanisms underlying abnormal fetal growth.
Source: Clinical Science - Category: Biomedical Science Authors: Tags: PublishAheadOfPrint Source Type: research

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CONCLUSIONS: A. muciniphila exerts a key role in the maintenance of intestinal health and in host metabolic modulation. Future studies could open new horizons towards its potential therapeutic applications in gastrointestinal and extra-intestinal diseases. PMID: 31599433 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Publication date: Available online 10 October 2019Source: Life SciencesAuthor(s): Yury Yu Borshchev, Yury P. Uspensky, Michael M. GalagudzaAbstractThe prevalence of dementia worldwide is growing at an alarming rate. A number of studies and meta-analyses have provided evidence for increased risk of dementia in patients with metabolic syndrome (MS) as compared to persons without MS. However, there are some reports demonstrating a lack of association between MS and increased dementia risk. In this review, taking into account the potential role of individual MS components in the pathogenesis of MS-related cognitive dysfunction...
Source: Life Sciences - Category: Biology Source Type: research
I read that chemical pathologists can specialize in metabolic medicine. I just stumbled accross this yesterday and found it quite intriguing My questions are: What do you guys treat and do, typical work and patient contact? All I hear its a relatively newer subspecialty and that they can treat any metabolic manifestations and are involved in parenteral nutrition. There's a fair amount of lab and patient contact which sounds cool. Involved in treating diabetes, hypertension, obesity... Metabolic medicine?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pathology Source Type: forums
"What we have done is not enough," says influential group as it launches a grim global report showing people are becoming heavier. Policies work, and will generate savings, but implementation is essential.Medscape Medical News
Source: Medscape Orthopaedics Headlines - Category: Orthopaedics Tags: Diabetes & Endocrinology News Source Type: news
"What we have done is not enough," says influential group as it launches a grim global report showing people are becoming heavier. Policies work, and will generate savings, but implementation is essential.Medscape Medical News
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Diabetes & Endocrinology News Source Type: news
ConclusionUrinalysis screening followed by evaluation of risk factors is a simple and efficient way to identify children with diabetes in schools.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
By DEBORAH A. COHEN Physical inactivity is a mounting challenge for America. In reviewing the 2013-2015 American time use survey, we found that most Americans report spending their daily leisure time watching screens, and devote only a small fraction of leisure time—24 minutes for men and 14 minutes for women—to physical activity. A recent longitudinal examination of the National Health and Nutrition Examination Survey showed that sitting time increased by an hour a day between 2007 and 2016, with the largest increases among adolescents ages 12-19 and adults, 20 years and older. As m...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Patients Amazon Deborah Cohen health and wellness hulu Netflix physical activity Rand Source Type: blogs
FRIDAY, Oct. 11, 2019 -- Poor glycemic control is associated with increased risks for stroke and death among patients with type 2 diabetes, according to a study published online Oct. 1 in Diabetes, Obesity and Metabolism. Alexander Zabala, M.D.,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
This study enrolled 14983 eligible subjects stratified into metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW), metabolically healthy obesity (MHO), metabolically unhealthy normal weight (MUNW), metabolically unhealthy overweight (MUOW), and metabolically unhealthy obesity (MUO) according to body mass index and metabolic syndrome status (ATP-III criteria). The metabolic healthy phenotype was defined as the absence of both metabolic syndrome and any known diabetes, coronary artery disease, stroke, hypertension or dyslipidemia. Early and advanced CKD were defined as eGFR
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
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