Regulation of Amino Acid Transporter Trafficking by mTORC1 in Primary Human Trophoblast cells is Mediated by the Ubiquitin Ligase Nedd4-2.

In conclusion, we have identified a novel link between mTORC1 signaling and ubiquitination, a common posttranslational modification. Because placental mTORC1 is inhibited in fetal growth restriction and activated in fetal overgrowth, we propose that regulation of placental amino acid transporter ubiquitination by mTORC1 and Nedd4-2 constitutes a molecular mechanisms underlying abnormal fetal growth.

Source: Clinical Science - November 25, 2015 Category: Biomedical Science Authors: Rosario, F. J., Dimasuay, K. G., Kanai, Y., Powell, T. L., Jansson, T. Tags: PublishAheadOfPrint Source Type: research