L-type Cav1.3 channels regulate ryanodine receptor-dependent Ca2+ release during sino-atrial node pacemaker activity

Conclusions
Cav1.3 channels play a critical role in the regulation of [Ca2+]i dynamics, providing an unanticipated mechanism for triggering local [Ca2+]i releases and thereby controlling pacemaker activity. Our study also provides an additional pathophysiological mechanism for congenital SAN dysfunction and heart block linked to Cav1.3 loss of function in humans.

Source: Cardiovascular Research - February 12, 2016 Category: Cardiology Authors: Torrente, A. G., Mesirca, P., Neco, P., Rizzetto, R., Dubel, S., Barrere, C., Sinegger-Brauns, M., Striessnig, J., Richard, S., Nargeot, J., Gomez, A. M., Mangoni, M. E. Tags: Ion Channels and Arrhythmias Source Type: research