Comment on “Hypercholesterolemia with consumption of PFOA-laced Western diets is dependent on strain and sex of mice” by Rebholz S.L. et al. Toxicology Reports 2016; 3: 46–54.

Publication date: Available online 11 February 2016 Source:Toxicology Reports Author(s): Hans M.G. Princen, Marianne G. Pouwer, Elsbet J. Pieterman A recent article in Toxicology Reports by [26] reported increased plasma cholesterol levels (primarily as HDL) in C57BL/6 (male and female) and BALB/c (male only) mice given high fat (Westernized) diet which also contained PFOA. The authors concluded that PFOA ingestion leads to hypercholesterolemia and they stated these data were “consistent with human observational findings”. There are several key factors which have not been considered in their study and we offer this letter to identify this important information. In particular, we feel that this conclusion needs more balance, particularly with respect to the relevance and translatability of their findings to the human situation.

Source: Toxicology Reports - February 11, 2016 Category: Toxicology Source Type: research