Using mental visual imagery to improve autobiographical memory and episodic future thinking in relapsing-remitting multiple sclerosis patients: A randomised-controlled trial study.

CONCLUSIONS: The control and stability groups' results ruled out nursing and test learning effects as explanations of AM/EFT improvement. These benefits were corroborated by the patients' comments, which indicated an effective MVI strategy transfer to daily life. Our results suggest that the MVI programme tackles a common cognitive process of scene construction present in AM and EFT. PMID: 26410206 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

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Conditions:   Multiple Sclerosis;   Gait Disorders, Neurologic;   Accidental Fall Interventions:   Behavioral: Backward Walking Training;   Behavioral: Forward Walking Training Sponsor:   Wayne State University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Multiple Sclerosis Intervention:   Diagnostic Test: Dual TAsk Sponsor:   University Hospital, Limoges Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Sadovnick D Abstract The relative roles of genes and environment (not intra-familial environment) and interactions thereof continue to confound better understanding of the pathogenesis of multiple sclerosis (MS) and can also impact recurrence risks for family members as well as genetic family studies. Strong evidence for non-familial environmental factors is suggested by the change in the sex ratio (female:male) of MS patients over the last four decades. PMID: 31519302 [PubMed - as supplied by publisher]
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
CONCLUSION: There is a high prevalence of CIM use among MS patients. Therefore, patient- physician communication about CIM use should be emphasized. PMID: 31519287 [PubMed - in process]
Source: Complementary Therapies in Medicine - Category: Complementary Medicine Authors: Tags: Complement Ther Med Source Type: research
by Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, Kenzo Yamamoto, Diwakar Bobbala, Subburaj Ilangumaran, Matthew D. Smith, Albert Lamontagne, Samir Jarjoura, Jean-Bernard Denault, V éronique Blais, Louis Gendron, Carles Vilariño-Güell, A. Dessa Sadovnick, Jenny P. Ting, Peter A. Calabresi, Abdelaziz Amrani, Denis Gris Nucleotide-binding, leucine-rich repeat containing X1 (NLRX1) is a mitochondria-located innate immune sensor that inhibits major pro-inflammatory pathways such as type I interferon and nuclear factor-κB signaling. We generated a novel, spontaneous, and rapidly progressing mouse...
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
Nature Reviews Neurology, Published online: 16 September 2019; doi:10.1038/s41582-019-0253-6In this Review, Dong and Yong summarize the mechanisms and consequences of T cell–microglia interactions in multiple sclerosis, discuss therapeutic approaches that affect these interactions and consider the challenges of translating preclinical knowledge in this area to humans.
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
CONCLUSIONS: Our data indicate that changes in lipoprotein profile and subclasses are preceded by insulin resistance and hyperinsulinemia in patients with newly diagnosed MS. PMID: 31517604 [PubMed - in process]
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
AbstractMultiple sclerosis (MS) is a devastating inflammatory disease of the central nervous system (CNS) associated with loss of myelin sheaths. The role of Schwan cells in the remyelination of MS lesions has been documented. However, the detailed steps of this process are unknown.Ninjurin 2 (NINJ2) encodes an adhesion protein with high expression in Schwann cells adjoining the distal piece of injured nerve. Based on the role of this protein in neurite outgrowth, it might participate in the process of nerve regeneration after nerve damage. In the present study, we genotyped twoNINJ2 single nucleotide polymorphisms (SNPs) ...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
AbstractThe aim of this study was to evaluate the immune-inflammatory, metabolic, and nitro-oxidative stress (IM&NO) biomarkers as predictors of disability in multiple sclerosis (MS) patients. A total of 122 patients with MS were included; their disability was evaluated using the Expanded Disability Status Scale (EDSS) and IM&NO biomarkers were evaluated in peripheral blood samples. Patients with EDSS ≥3 were older and showed higher homocysteine, uric acid, advanced oxidized protein products (AOPP) and low-density lipoprotein (LDL)-cholesterol and higher rate of metabolic syndrome (MetS), while high-density lipoprotein ...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
AbstractMultiple Sclerosis (MS) is a chronic inflammatory disease causing demyelination and neurodegeneration in the central nervous system (CNS). Although the exact etiology of MS is still unclear, both genetic and environmental elements are regarded as causative factors. Environmental factors can induce a cascade of events in immune system leading to neuronal death and nerve demyelination. This paper aims to compare the peripheral transcript levels ofErmin (ERMN) (a gene with putative role in cytoskeletal rearrangements during myelinogenesis) andListerin E3 Ubiquitin Protein Ligase 1 (LTN1) (a gene with functions in regu...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
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