Abstract B09: Mitochondrial respiration controlled by survivin directs mitochondrial dynamics and tumor cell invasion

In this study, with the use of sirRNA and pharmacological approaches against survivin, as well as protein reconstitution experiments, we dissect the role of mitochondrial survivin in modulating tumor bioenergetics. Biochemically, this study identifies mitochondrial survivin as part of a multi-protein complex with mitochondrial chaperone TRAP-1 and oxidative phosphorylation Complex II subunits. Survivin recruitment to this complex ensures protein folding and oxidative phosphorylation activity. Interference with this pathway inhibits cellular respiration, ATP production and induces cellular starvation. Functionally, this multiprotein complex suppresses tumor cell migration, invasion and affects metastatic progression in vivo. Overall, this study identifies mitochondrial bioenergetics, regulated by mitochondrial survivin, as a modulator of tumor cell invasion and metastasis.Citation Format: Dayana B. Rivadeneira, M. Cecilia Caino, Jae Ho Seo, Alessia Angelin, Wallace C. Douglas, Lucia R. Languino, Dario C. Altieri. Mitochondrial respiration controlled by survivin directs mitochondrial dynamics and tumor cell invasion. [abstract]. In: Proceedings of the AACR Special Conference: Metabolism and Cancer; Jun 7-10, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(1_Suppl):Abstract nr B09.

Source: Molecular Cancer Research - January 15, 2016 Category: Cancer & Oncology Authors: Rivadeneira, D. B., Caino, M. C., Seo, J. H., Angelin, A., Douglas, W. C., Languino, L. R., Altieri, D. C. Tags: Signaling Pathways and Cancer Metabolism: Poster Presentations - Proffered Abstracts Source Type: research