Association of polymorphisms with a family history of cancer and the presence of germline mutations in the BRCA1/BRCA2 genes

Conclusion The results presented here provide interesting data on the modifying effect of polymorphisms on a family history of cancer; this may be a variable to consider in the analysis of tumor diversity, and of the family history observed in families with hereditary breast cancer (even in those harboring the same type of genetic alteration).

http://link.springer.com/10.1186/s13053-015-0042-1

Source: Hereditary Cancer in Clinical Practice - January 13, 2016 Category: Cancer & Oncology Source Type: research