Peripartum and 'Idiopathic' Cardiomyopathies Share Gene VariantsPeripartum and 'Idiopathic' Cardiomyopathies Share Gene Variants

Pregnancy-related cardiomyopathy may share genetic underpinnings with idiopathic dilated cardiomyopathy, say researchers. "For the first time, we have an explanation for a subset of these women that is quite novel." Heartwire from Medscape
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news

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Authors: Hänselmann A, Veltmann C, Bauersachs J, Berliner D Abstract Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy and one of the most common causes of heart failure. It is characterized by left or biventricular dilation and a reduced systolic function. The causes are manifold and range from myocarditis to alcohol and other toxins, to rheumatological, endocrinological, and metabolic diseases. Peripartum cardiomyopathy is a special form that occurs at the end of or shortly after pregnancy. Genetic mutations can be detected in approximately 30-50% of DCM patients. Owing to the ...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
g;berg M Abstract BACKGROUND: Incidence rates of cardiomyopathies, which are a common cause of heart failure in young people, have increased during the last decades. An association between body weight in adolescence and future cardiomyopathy among men was recently identified. Whether or not this holds true also for women is unknown. The aim was therefore to determine whether for young women being overweight or obese is associated with a higher risk of developing cardiomyopathy. METHODS: This was a registry-based national prospective cohort study with data collected from the Swedish Medical Birth Register, 198...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
AbstractPurpose of ReviewGenetic studies have identified an increasing number of culprit disease genes in patients with dilated cardiomyopathy (DCM). While these studies were originally conducted in patients with primary DCM, recent research has identified culprit mutations among patients who develop DCM in response to an environmental exposure. This review will summarize the genetic architecture of DCM secondary to alcohol, anthracyclines, and pregnancy, as well as the potential modifying role of exercise.Recent FindingsMutations in DCM-associated genes are identified in 10 –20% of patients categorized as having a s...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
We present a case of a 44-year-old pregnant female known for DCM with low ejection fraction who underwent an elective cesarean section and tubal ligation. The patient was transferred to the intensive care unit in a stable condition with a favorable outcome. Awareness about the appropriate anesthetic management for this type of patients is of paramount importance because similar cases are likely to be encountered with the advances in modern medicine.
Source: Saudi Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research
Diagnostic criteria for peripartum cardiomyopathy are: Development of heart failure in the last month of pregnancy or within 5 months after delivery Left ventricular systolic dysfunction with ejection fraction less than 45% No other identifiable cause for heart failure No recognized heart disease before the last month of pregnancy Reference van Spaendonck-Zwarts KY1, van Tintelen JP, van Veldhuisen DJ, van der Werf R, Jongbloed JD, Paulus WJ, Dooijes D, van den Berg MP. Peripartum cardiomyopathy as a part of familial dilated cardiomyopathy. Circulation. 2010 May 25;121(20):2169-75.
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Source Type: blogs
Abstract Early Embryonic Arrest (EEA) is one of the major causes of female infertility. Genetic factors including specific genes and miRNAs may play pivotal roles on EEA. However, it is not well defined what genes and micro RNAs participate the pathophysiological alterations of EEA. In this work, we compared the Transcriptome -Seq and microRNA profiles from three pairs of villi (three EEA patients and three normal pregnancy, NP). We first confirmed the array data by qPCR with ten randomly selected differentially expressed genes and ten differentially expressed miRNAs in villi from 20 EEA and 20 NP controls. We nex...
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
Several serious disorders may present during pregnancy or postpartum with thrombotic microangiopathy (p-TMA). Signs of microangiopathic hemolytic anemia and thrombocytopenia may arise due to pregnancy complications such as severe preeclampsia (sPE) and HELLP-syndrome (hemolysis, elevated liver enzymes, and low platelets) or severe independent diseases: atypical hemolytic uremic syndrome (aHUS), thrombotic thrombocytopenic purpura (TTP). Recent evidence and clinical similarities suggest a link sPE/HELLP to aHUS, a disease of excessive activation of the alternative complement pathway. Pregnancy-associated aHUS is a severe di...
Source: Blood - Category: Hematology Authors: Tags: 903. Outcomes Research-Non-Malignant Hematology: Poster III Source Type: research
AbstractPurpose of reviewThis review summarizes the pathophysiology, diagnosis, and treatment of peripartum cardiomyopathy (PPCM), with a focus on recent discoveries of clinical relevance.Recent findingsAn increase in oxidative stress and anti-angiogenic activity play key roles in the pathophysiology of peripartum cardiomyopathy. Therapies that target this dysregulation may have a future role in treatment. Suppression of prolactin release using bromocriptine, a dopamine-receptor antagonist, has been associated with more favorable outcomes in small studies but more research is needed. Similarly, VEGF agonists may prove to b...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
This article is part of the Mini Review Series from the Varenna 2017 meeting of the Working Group of Myocardial Function of the European Society of Cardiology.
Source: Cardiovascular Research - Category: Cardiology Source Type: research
Peripartum cardiomyopathy is associated with significant risks of decline in left ventricular function and adverse maternal and fetal outcome in subsequent pregnancy. The risks of pregnancy in women with dilated cardiomyopathy are unclear. We aimed to assess the outcome of pregnancy in women with dilated cardiomyopathy seen at our institution and to review the literature on this subject.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Original Article Source Type: research
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