Peripartum and 'Idiopathic' Cardiomyopathies Share Gene VariantsPeripartum and 'Idiopathic' Cardiomyopathies Share Gene Variants

Pregnancy-related cardiomyopathy may share genetic underpinnings with idiopathic dilated cardiomyopathy, say researchers. "For the first time, we have an explanation for a subset of these women that is quite novel." Heartwire from Medscape
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news

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Diagnostic criteria for peripartum cardiomyopathy are: Development of heart failure in the last month of pregnancy or within 5 months after delivery Left ventricular systolic dysfunction with ejection fraction less than 45% No other identifiable cause for heart failure No recognized heart disease before the last month of pregnancy Reference van Spaendonck-Zwarts KY1, van Tintelen JP, van Veldhuisen DJ, van der Werf R, Jongbloed JD, Paulus WJ, Dooijes D, van den Berg MP. Peripartum cardiomyopathy as a part of familial dilated cardiomyopathy. Circulation. 2010 May 25;121(20):2169-75.
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Source Type: blogs
Abstract Early Embryonic Arrest (EEA) is one of the major causes of female infertility. Genetic factors including specific genes and miRNAs may play pivotal roles on EEA. However, it is not well defined what genes and micro RNAs participate the pathophysiological alterations of EEA. In this work, we compared the Transcriptome -Seq and microRNA profiles from three pairs of villi (three EEA patients and three normal pregnancy, NP). We first confirmed the array data by qPCR with ten randomly selected differentially expressed genes and ten differentially expressed miRNAs in villi from 20 EEA and 20 NP controls. We nex...
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
Several serious disorders may present during pregnancy or postpartum with thrombotic microangiopathy (p-TMA). Signs of microangiopathic hemolytic anemia and thrombocytopenia may arise due to pregnancy complications such as severe preeclampsia (sPE) and HELLP-syndrome (hemolysis, elevated liver enzymes, and low platelets) or severe independent diseases: atypical hemolytic uremic syndrome (aHUS), thrombotic thrombocytopenic purpura (TTP). Recent evidence and clinical similarities suggest a link sPE/HELLP to aHUS, a disease of excessive activation of the alternative complement pathway. Pregnancy-associated aHUS is a severe di...
Source: Blood - Category: Hematology Authors: Tags: 903. Outcomes Research-Non-Malignant Hematology: Poster III Source Type: research
AbstractPurpose of reviewThis review summarizes the pathophysiology, diagnosis, and treatment of peripartum cardiomyopathy (PPCM), with a focus on recent discoveries of clinical relevance.Recent findingsAn increase in oxidative stress and anti-angiogenic activity play key roles in the pathophysiology of peripartum cardiomyopathy. Therapies that target this dysregulation may have a future role in treatment. Suppression of prolactin release using bromocriptine, a dopamine-receptor antagonist, has been associated with more favorable outcomes in small studies but more research is needed. Similarly, VEGF agonists may prove to b...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
This article is part of the Mini Review Series from the Varenna 2017 meeting of the Working Group of Myocardial Function of the European Society of Cardiology.
Source: Cardiovascular Research - Category: Cardiology Source Type: research
Peripartum cardiomyopathy is associated with significant risks of decline in left ventricular function and adverse maternal and fetal outcome in subsequent pregnancy. The risks of pregnancy in women with dilated cardiomyopathy are unclear. We aimed to assess the outcome of pregnancy in women with dilated cardiomyopathy seen at our institution and to review the literature on this subject.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Original Article Source Type: research
I thank Wang et  al. for their review regarding trauma-related thyroid storm (1). Pulmonary arterial hypertension has been reported in 44%–65% of patients with uncontrolled hyperthyroidism due to Grave's disease or toxic multinodular goiter (2,3). Dilated cardiomyopathy and Takotsubo cardiomyopathy can also comp licate hyperthyroidism (4). Echocardiography in the emergency department is essential to exclude these cardiovascular complications, which can be aggravated by β-blockers. This is particularly critical in late pregnancy, given the significant maternal mortality with delivery in the setting...
Source: The Journal of Emergency Medicine - Category: Emergency Medicine Authors: Tags: Letter to the Editor Source Type: research
Time limit: 0 Quiz-summary 0 of 20 questions completed Questions: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Information This test series requires login for attempting. You can login easily with your Facebook account (Use the CONNECT WITH icon on the upper part of right sidebar displaying t...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology Source Type: blogs
Peripartum cardiomyopathy (PPCM) is a rare disease that occurs during pregnancy and up to 5 months postpartum, in previously healthy women. Recent studies have revealed that 40% of PPCM patients complicated with pregnancy-induced hypertension, and from 10 to 20% of the PPCM patients had genetic etiology of dilated cardiomyopathy (DCM). A Japanese nationwide survey revealed that PPCM patients with pregnancy-induced hypertension had better cardiac function in the chronic phase, although the rate of death and cardiac parameters at diagnosis were similar in PPCM patients with or without pregnancy-induced hypertension.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
AbstractPeripartum cardiomyopathy (PPCM) is an uncommon complication of pregnancy. Early case reports identified overlap between familial dilated cardiomyopathy (DCM) and PPCM, although the degree of overlap is largely unknown. Other evidence supporting a contribution from gene mutations in PPCM includes familial occurrence, genome-wide association studies, variable prevalence among different regions and ethnicities, and more recent investigations of panels of genes for mutations among women with PPCM. Murine models implicate the role of altered metabolism and increased free radical stress to the heart during pregnancy, wh...
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research
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