Molecules, Vol. 21, Pages 31: Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7
Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3–5. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent activity against the U937 cell line with an IC50 value of 4.2 μM.
Source: Molecules - Category: Chemistry Authors: Yu WangDa-Hong LiZhan-Lin LiYan-Jun SunHui-Ming HuaTao LiuJiao Bai Tags: Article Source Type: research
More News: Aspergillus | Cancer | Cancer & Oncology | Chemistry | Leukemia | Lymphoma | Prostate Cancer