Response to Letter to the Editor from Dr. Dale Ding: Molecular insights into aneurysmal subarachnoid hemorrhage and cerebral vasospasm from analysis of coated-platelets

We thank Dr. Dale Ding for his thoughtful comments. We agree that the current data , in conjunction with prior results showing lower levels of coated-platelets in spontaneous intracerebral hemorrhage (ICH) and an inverse relationship between these levels and the bleed size , as well as the presence of lower coated-platelet levels in patients with early hemorrhagic transformation after non-lacunar stroke and in dogs with a bleeding diathesis support a role in hemostasis for this subset of procoagulant platelets. We also agree that a critical study with potential significant impact would be monitoring of coated-platelet levels in patients with unruptured aneurysms to identify a potential link with subsequent rupture risk; this is one focus of our future efforts.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letters to the Editor Source Type: research