A case of syndrome of inappropriate scretion of anti-diuretic hormone associated with sodium valproate.

We report a rare case of the concurrent manifestation of central diabetes insipidus (CDI) and type 2 diabetes mellitus (DM). A 56 year-old man was diagnosed as a type 2 DM on the basis of hyperglycemia with polyuria and polydipsia at a local clinic two months ago and started an oral hypoglycemic medication, but resulted in no symptomatic improvement at all. Upon admission to the university hospital, the patient's initial fasting blood sugar level was 140 mg/dL, and he showed polydipsic and polyuric conditions more than 8 L urine/day. Despite the hyperglycemia controlled with metformin and diet, his symptoms persisted. Further investigations including water deprivation test confirmed the coexisting CDI of unknown origin, and the patient's symptoms including an intense thirst were markedly improved by desmopressin nasal spray (10 µg/day). The possibility of a common origin of CDI and type 2 DM is raised in a review of the few relevant adult cases in the literature. PMID: 23508789 [PubMed]
Source: Electrolyte and Blood Pressure - Category: Internal Medicine Tags: Electrolyte Blood Press Source Type: research

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We report the case of a 43-year-old male with significant polyuria and polydipsia (>10 l/24 h) developed progressively over almost a year. Six months before admission in our department, uncontrolled type 2 DM was diagnosed and polyuria was interpreted as a result of his significant glycosuria. However, despite adequate sulfonylurea treatment with normalization of glycemic levels, polyuria persisted and even worsened. Upon admission, polyuria with a very low urine specific gravity and osmolality was noted (suggestive of increased water loss). A water deprivation test was performed and confirmed central diabetes...
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