Glycaemic Control in Cardiac Surgery Patients: A Double-Edged Sword.

Glycaemic Control in Cardiac Surgery Patients: A Double-Edged Sword.
Curr Vasc Pharmacol. 2014 Feb 24;
Authors: Krzych LJ, Wybraniec MT
Abstract
Glycaemic management is of paramount importance in the cardiac surgery setting. A growing body of evidence confirms a J-shaped relationship between blood glucose (BG) level and perioperative morbidity and mortality. On one hand, acute hypoglycaemia causes irreversible cerebral damage. On the other hand, hyperglycaemia increases the risk of infections, acute kidney injury, atrial fibrillation, low cardiac output syndrome, cerebrovascular accidents and cognitive impairment. Also, high BGvariability, even within the therapeutic window, may deteriorate the outcome. Therefore, moderate perioperative insulin management is usually recommended, with target BGadjusted to individual needs and possibilities. Continuous BGmonitoring is a promising tool that should help practitioners in everyday decision-making process of glycaemic control. This review summarises the current evidence-based knowledge on the perioperative management of hyperglycaemia.
PMID: 24568136 [PubMed - as supplied by publisher]

Source: Current Vascular Pharmacology - February 24, 2014 Category: Drugs & Pharmacology Authors: Krzych LJ, Wybraniec MT Tags: Curr Vasc Pharmacol Source Type: research