High glucose induces human endothelial dysfunction through an Axl-dependent mechanism

Conclusions: This study demonstrates that HG can alter Gas6/Axl signaling and may through Akt and VEGF/VEGFR2 downstream molecules and suggests that Gas6/Axl may involve in HG-induced EC dysfunction.

http://www.cardiab.com/content/13/1/53

Source: Cardiovascular Diabetology - February 26, 2014 Category: Cardiology Authors: Chien-Hsing LeeYi-Shing ShiehFone-Ching HsiaoFeng-Chih KuoChih-Yuan LinChang-Hsun HsiehYi-Jen Hung Source Type: research