Invest in pathology services to boost diagnosis and cut costs, urges report

Royal College of Pathologists sets out priorities in response to Five Year Forward ViewRelated items from OnMedicaOvarian cancer study paves way for personalised medicineTesting and treating MRSA is cost-effectiveBlood test could help predict breast cancer survivalPathologist calls for post mortem rate to be halvedNHS Medical Director launches pathology review
Source: OnMedica Latest News - Category: UK Health Source Type: news

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This study is aimed at developing coriander oil into a nanoemulgel and evaluating its antimicrobial and anticancer effects. Coriander (Coriandrum sativum) oil was developed into a nanoemulgel by using a self-nanoemulsifying technique with Tween 80 and Span 80. Hydrogel material (Carbopol 940) was then incorporated into the nanoemulsion and mixed well. After this, we evaluated the particle size, polydispersity index (PDI), rheology, antimicrobial effect, and cytotoxic activity. The nanoemulsion had a PDI of 0.188 and a particle size of 165.72 nm. Interesting results were obtained with the nanoemulgel against different types...
Source: Biomed Res - Category: Research Authors: Source Type: research
Source: Anti-Cancer Agents in Medicinal Chemistry - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
élia Duarte Patrícia Rijo The antimicrobial evaluation of twelve natural and hemisynthetic isopimarane diterpenes are reported. The compounds were evaluated against a panel of Gram-positive bacteria, including two methicillin-resistant Staphylococcus aureus (MRSA) strains and one vancomycin-resistant Enterococcus (VRE) strain. Only natural compounds 7,15-isopimaradien-19-ol (1) and 19-acetoxy-7,15-isopimaradien-3β-ol (6) showed promising results. Isopimarane (1) was the most active, showing MIC values between 6.76 µM against S. aureus (ATCC 43866) and 216.62 µM against E. fa...
Source: Molecules - Category: Chemistry Authors: Tags: Communication Source Type: research
Abstract Antimicrobial peptides (AMP) with anticancer activity have drawn remarkable attention in modern treatments. However, long peptide length and protease instability are the most addressing factors, which hampers their further development as therapeutic agents. In view of this, herein, we designed and synthesized a series of AZT-based cationic small molecule incorporating a variety of hydrophobic groups and cationic charges, including amine and guanidine groups to mimic the amphipathic structure of AMPs. These compounds were evaluated for their antibacterial activity against Gram-positive and Gram-negative ba...
Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Tags: Eur J Med Chem Source Type: research
In this study, we firstly tested the effects of QJSB on leucopenia using mice induced by cyclophosphamide. Our results suggested that QJSB significantly raised the number of peripheral white blood cells, platelets and nucleated bone marrow cells. Additionally, it markedly enhanced the cell viability and promoted the colony formation of bone marrow mononuclear cells. Furthermore, it reversed the serum cytokines IL-6 and G-CSF disorders. Then, using transcriptomics datasets and metabonomic datasets, we integrated transcriptomics-based network pharmacology and metabolomics technologies to investigate the mechanism of action o...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study aimed to contribute to the need of finding new and more effective bioactive molecules against several of the earlier mentioned threats faced by human kind nowadays. For this, eighteen species from the Actinomycetales previously isolated from Erylus spp. sponges collected in Portuguese marine waters (Açores, Madeira, and continental shelf) were screened for antimicrobial, anti-cancer, anti-parasitic and anti-obesogenic activities. Materials and Methods Biological Material The bacteria under study belong to the order Actinomycetales within the phylum Actinobacteria and were isolated from marine sponges o...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionOur data revealed significant antimicrobial and antioxidant effects ofC. siliquastrum that contributes significantly to the cytotoxicity of cancer cells that requires further detailed studies.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
CONCLUSION: A small library of heterocyclic-containing chalcones was developed and initial screening demonstrates modest activity against cancers, bacteria, and fungi. PMID: 29065840 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - Category: Chemistry Authors: Tags: Med Chem Source Type: research
Publication date: 1 October 2017 Source:Journal of Organometallic Chemistry, Volume 846 Author(s): Parichad Chuklin, Vachirawit Chalermpanaphan, Tidarat Nhukeaw, Saowanit Saithong, Kittipong Chainok, Sauwalak Phongpaichit, Adisorn Ratanaphan, Nararak Leesakul Two new arene compounds containing bis-diphosphinomethane (dppm) and tert-butylpyridine (tbp) ligands as important components in ruthenium(II) complexes were synthesized and characterized by X-ray crystallography, and spectroscopy of 1H NMR, 13C NMR, 2D-NMR, FTIR and CHN analysis. The synthesized complexes were evaluated in vitro as anticancer agents of human br...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research
I get asked often, am I getting better? Have any of my doctors found a miraculous treatment for me?The answers are and always will be a big fat'no'.There are different kinds of ailments out there. They are (in my non medical terminology):Acute - an ailment which happens and gets better. Think a cut, the flu, appendicitis, Lyme disease.Chronic - an ailment which occurs and lasts and lasts and lasts. Think things like arthritis, fibromyalgia, degenerating disks, etc.Terminal - an ailment which will kill you. "Terminal illnesses or infections are consideredincurable when there are no conservative therapies available whic...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: ailments chronic conditions medical treatment pain management Source Type: blogs
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