Compound A modulates steroid insensitive chemokines in airway smooth muscle cells via IRF-1 dependent and independent pathways

In conclusion, CpdA suppresses production of GC-resistant chemokines via IRF-1 dependent and independent mechanisms.Targeting CpdA sensitive pathways in ASM cells represents an alternative therapeutic approach for GC insensitivity treatment in asthma.

Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Gavrila, A., Chachi, L., Tliba, O., Brightling, C., Amrani, Y. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research