Multiple sclerosis patient-derived CSF induces transcriptional changes in proliferating oligodendrocyte progenitors

Conclusions:
Despite evidence of morphological differentiation induced by exposure to CSF of PPMS patients, the overall transcriptional response elicited in cultured OPCs was consistent with the activation of an aberrant transcriptional programme.

Source: Multiple Sclerosis - October 29, 2015 Category: Neurology Authors: Haines, J. D., Vidaurre, O. G., Zhang, F., Riffo-Campos, A. L., Castillo, J., Casanova, B., Casaccia, P., Lopez-Rodas, G. Tags: Original Research Papers Source Type: research