Species specificity of a ribosome from a pathogen [Biophysics and Computational Biology]

The emergence of bacterial multidrug resistance to antibiotics threatens to cause regression to the preantibiotic era. Here we present the crystal structure of the large ribosomal subunit from Staphylococcus aureus, a versatile Gram-positive aggressive pathogen, and its complexes with the known antibiotics linezolid and telithromycin, as well as with a...

Source: Proceedings of the National Academy of Sciences - October 27, 2015 Category: Science Authors: Eyal, Z., Matzov, D., Krupkin, M., Wekselman, I., Paukner, S., Zimmerman, E., Rozenberg, H., Bashan, A., Yonath, A. Tags: PNAS Plus Source Type: research