Notch Increased Vitronection Adhesion Protects myeloma cells from drug induced Apoptosis.

This study first connected Notch signaling, VTN adhesion and drug resistance together. Therefore, blocking αvβ5 receptor with antibody or knock down approach would be a novel promising strategy to treat MM. PMID: 26494298 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26494298?dopt=Abstract

Source: Biochemical and Biophysical Research communications - October 19, 2015 Category: Biochemistry Authors: Ding Y, Shen Y Tags: Biochem Biophys Res Commun Source Type: research