Bismuth, lansoprazole, amoxicillin and metronidazole or clarithromycin as first-line Helicobacter pylori therapy

Conclusions
These results suggest that amoxicillin can substitute for tetracycline in modified 14 day bismuth quadruple therapy as first-line treatment and still overcome metronidazole resistance in areas with high prevalence of metronidazole and clarithromycin resistance. Using clarithromycin instead of metronidazole was only effective in the presence of susceptible strains.

Trial registration number
NCT02175901.

Source: Gut - October 8, 2015 Category: Gastroenterology Authors: Zhang, W., Chen, Q., Liang, X., Liu, W., Xiao, S., Graham, D. Y., Lu, H. Tags: Helicobacter pylori Source Type: research