Chemically induced dimerization: reversible and spatiotemporal control of protein function in cells.

Chemically induced dimerization: reversible and spatiotemporal control of protein function in cells. Curr Opin Chem Biol. 2015 Sep 29;28:194-201 Authors: Voß S, Klewer L, Wu YW Abstract Small-molecule perturbation of biological systems is able to tackle biological problems that are not accessible by classical genetic interference methods. Chemically induced dimerization (CID) has been used as a valuable tool to study various biological processes. Recent years have seen tremendous progress in the development of orthogonal and reversible CID systems. These new systems allow control over protein function with unprecedented precision and spatiotemporal resolution. While the primary application of CID has been on dissecting signal transductions, new emerging approaches have extended the scope of this technique to elucidating membrane and protein trafficking. PMID: 26431673 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research