Immunopathogenesis of olmesartan‐associated enteropathy

ConclusionsOlmesartan‐associated enteropathy shares many features with coeliac disease, including symptoms and immunopathogenic pathways, such as increased numbers of CD8+ cells and corresponding overexpression of IL15 by epithelial cells. Taken together, the treatment of epithelial cells with olmesartan medoxomil induces a response by intestinal epithelial cells that is similar to the innate effects of gluten upon the epithelium of coeliac patients.

Source: Alimentary Pharmacology and Therapeutics - October 1, 2015 Category: Drugs & Pharmacology Authors: E. V. Marietta, A. M. Nadeau, A. K. Cartee, I. Singh, A. Rishi, R. S. Choung, T.‐T. Wu, A. Rubio‐Tapia, J. A. Murray Tags: Original Article Source Type: research