Circulating Levels of Urokinase-Type Plasminogen Activator Receptor and D-Dimer in Patients With Hematological Malignancies

Conclusion We found differences in D-D serum levels and soluble uPAR between control participants and patients with lymphoma. These results indicate that D-D serum levels and soluble uPAR should be considered biomarkers of response and survival in patients with lymphoma. Micro-Abstract In this study we aimed to estimate sera levels of urokinase plasminogen activator receptor (uPAR) and D-dimer (D-D) as fibrinolysis markers and to determine their association with outcome. We found an increased frequency of positive D-D. Highest sera levels of D-D and soluble uPAR were detected for lymphoma patients versus control participants. In our population, these biomarkers were found to be related with treatment response and survival.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research