Researchers Grow Human Lung In A Lab
Researchers at the University of Texas Medical Branch (UTMB) have successfully grown a human lung in a laboratory. This is the first time such an accomplishment has been achieved.According to a report published by CNN, the lungs were grown using tissue from the lungs of two children who had died from trauma, most likely a car accident. Although these lungs had been too damaged to use in a transplant, they still had some healthy tissue.
Authors: Ceylan B, Yilmaz M, Beköz HS, Ramadan S, Ertan Akan G, Mert A Abstract Invasive aspergillosis is a severe infection that generally involves the lungs. Primary gastrointestinal aspergillosis is the least common form of invasive aspergillosis. A patient aged 65 years developed a febrile neutropenic episode following an autologous stem cell transplant for plasmacytoid variant diffuse large B-cell gastric non-Hodgkin's lymphoma. He had abdominal pain on the second day of the febrile neutropenic episode and ileus occurred on the sixth day. His general condition deteriorated despite broad spectrum antibioti...
I read with great interest the original article by Oishi and colleagues1 and the corresponding letter to the Editor composed by Katz and colleagues. Oishi and colleagues' work is one of the most recent publications from the Toronto lung transplant laboratories and has to be interpreted as such. Having established a protocol, which can be used to safely perfuse human donor lungs ex vivo, the research group has consequently taken the next step and applies this platform to treat and improve organs.
Natalie Jarvis has been inundated with offers of help since speaking out last week about the significant financial costs faced by Atlantic Canadian patients who must move to Toronto for lung transplants, and now she's asking people to help others in similar situations.
AbstractIntroductionThere is a strong association between cystic fibrosis and malnutrition, mainly because of the higher energy needs combined with lower intake. There is also a well-established correlation between good nutritional status and better lung function. To date, however, there are no studies examining nutritional status in childhood and adult lung function. To respond to this need, this innovative study explored the long-term correlations between nutritional status in childhood and lung function in adulthood for the same patient population.MethodsA retrospective patient file study was conducted to identify putat...
PMID: 30884244 [PubMed - as supplied by publisher]
Frailty is common in adults with end-stage lung disease and is associated with death before and after lung transplantation. We aimed to determine whether frailty changes from before to after lung transplant.
END-STAGE HEART FAILURE (HF) results from a myriad of etiologies and represents a major financial and healthcare burden.1 Since 1983, nearly 150,000 pediatric and adult heart transplants have been reported to the International Society for Heart and Lung Transplantation (ISHLT) Registry, with medical advancements in perioperative care resulting in improved patient outcomes over time.2 This paper aims to assess outcomes within the field of heart transplantation. The authors will focus on historical context, current demographics, indications, and contraindications for transplantation.
Right-sided heart failure develops in lung transplantation candidates on prolonged peripheral extracorporeal membrane oxygenation support and is a major determinant of mortality. The use of central venoarterial extracorporeal membrane oxygenation for bridging of right-sided heart failure to lung transplantation was evaluated.
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
We present a CF-patient with disseminated Scedosporium apiospermum infection after lung transplantation. The patient had skin, surgical wound, spinal cord, and brain involvements. She recovered fully after prolonged course of voriconazole treatment.