Spironolactone ameliorates arterial medial calcification in uremic rats: the role of mineralocorticoid receptor signaling in vascular calcification.

In conclusion, SPL dose-dependently inhibits the progression of VC by suppressing MR signaling, local inflammation, osteogenic transition, and apoptosis in the aortas of CKD rats.
PMID: 26336165 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - September 2, 2015 Category: Urology & Nephrology Authors: Tatsumoto N, Yamada S, Tokumoto M, Eriguchi M, Noguchi H, Torisu K, Tsuruya K, Kitazono T Tags: Am J Physiol Renal Physiol Source Type: research