Insulin Resistance May Contribute to Upregulation of Adhesion Molecules on Endothelial Cells in Psoriatic Plaques.

Insulin Resistance May Contribute to Upregulation of Adhesion Molecules on Endothelial Cells in Psoriatic Plaques. Acta Derm Venereol. 2015 Aug 28; Authors: Schlüter K, Diehl S, Lang V, Kaufmann R, Boehncke WH, Bürger C Abstract Psoriasis primarily affects the skin, but also has a systemic dimension and is associated with severe comorbidities. Since endothelial cells play an important role in psoriasis as well as in the development of cardiovascular comorbidities, we investigated whether a common mechanism, namely cytokine-induced insulin resistance, underlies both pathologies. Activation of the insulin pathway was studied in psoriatic skin and dermal endothelial cells. Expression of adhesion molecules was assessed by flow cytometry, as well as their biological function in flow chamber experiments. The phosphorylation status of Akt, a central kinase in the insulin pathway, suggests that endothelial cells within psoriatic plaques are rendered insulin resistant by pro-inflammatory cytokines. Insulin counteracts the expression of adhesion molecules, but has limited effects on interactions between T cells and endothelial cells. Pro-inflammatory cytokines induce insulin resistance in endothelial cells, which may contribute to the development of the inflammatory infiltrate in psoriasis. PMID: 26315601 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

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Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Conditions:   Plaque Psoriasis;   Non-alcoholic Fatty Liver Disease Interventions:   Biological: Investigational Arm - secukinumab;   Biological: Control Arm - placebo Sponsor:   Novartis Pharmaceuticals Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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Source: Medscape Today Headlines - Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news
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Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Tech Jessica DaMassa WTF Health Almirall Barcelona Health Hub Barcelona Health Hub Summit 2019 digital health Digital health funding digital therapeutics dtx Francesca Wuttke Pharma pharmaceuticals Source Type: blogs
Authors: Enciso-Vargas M, Alvarado-Ruíz L, Suárez-Villanueva AS, Macías-Barragán J, Montoya-Buelna M, Oceguera-Contreras E, Alvarado-Navarro A, Graciano-Machuca O Abstract Background: Psoriatic Arthritis (PsA) is a seronegative spondyloarthropathy frequently associated with psoriasis. Studies have shown different members of the KIR (Killer Immunoglobulin-like Receptor) gene family may act as potential susceptibility factors; however, data have been inconsistent or with a reduced sample size. Therefore, the objective of this investigation was to determine associations between KIR genes an...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Source: Journal of Inflammation Research - Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
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Source: BMC Medical Genomics - Category: Genetics & Stem Cells Authors: Tags: Research article Source Type: research
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