do you mind sharing what post-transplant dosage you are currently on? thx
Conditions: Cystic Fibrosis; Death; Lung Transplantation Intervention: Diagnostic Test: Lung function testing Sponsors: University Hospital Inselspital, Berne; Lindenhofspital Completed
A pediatric patient with cystic fibrosis and a double-lung transplant received a genetically engineered 3-phage cocktail to treat a life-threatening antibiotic-resistant Mycobacterium abscessus infection for which all standard therapeutic options had been exhausted. Over 7 months of twice-daily intravenous infusions, as well as daily topical phage therapy, the 15-year-old patient ’s surgical wound and skin lesions healed gradually and her lung and liver function improved. No adverse reactions to the treatment were reported.
We report the case of a 23-year-old woman with a history of cystic fibrosis and bilung transplantation, who presented clinically cervical swollen lymph nodes with alteration of her general state. 18F-FDG PET/CT was performed because of lymphoma suspicion and showed cervical and pelvic hypermetabolic lymphadenopathies, with linear vaginal hypermetabolism. There was an increase of lactate dehydrogenase, and Epstein-Barr virus detection was negative. A right cervical lymph node biopsy was performed, with no lymphoma involvement. Complementary microbiological investigations showed positive results for Gardnerella vaginalis.18F...
Conclusion: These results demonstrate the high prevalence of extrapulmonary comorbidities in transplanted CF adult patients particularly CFRD. We highlight the need for specific surveillance and prevention for transplanted CF patients who were already treated for extra espiratory comorbidities before lung transplantation, due to the potential aggravation of their comorbidities after transplantation. PMID: 31267788 [PubMed - as supplied by publisher]
Since lung transplantation became a viable option for cystic fibrosis (CF) lung disease, adult transplant recipients with CF have superior survival compared to all the other major diagnostic indications. However, among adults, recipients with CF have a younger age at transplant in comparison to other transplant recipients. Over time, the frequency and proportion of lung transplants for CF has increased for adults in comparison to children. Using a large international transplant registry, we investigated time trends in numbers of transplants, age at transplant, and post-transplant survival and cause of death for recipients with CF.
New variables ID the sickest waitlist candidates with cystic fibrosis, chronic obstructive pulmonary disease
Elizabeth Dolan, 28, was never expected to live past age 10 due to her incurable lung condition. On February 1, she got a double lung transplant in California and is breathing easier than ever.
(Cleveland Clinic) Implemented in 2005, the lung allocation score is used to prioritize patients awaiting lung transplants in the US. Sicker transplant candidates have a higher calculated score and are placed at the top of the list. But a recent study led by Maryam Valapour, M.D., MPP, director of Lung Transplant Outcomes in Cleveland Clinic's Respiratory Institute, found including new clinical variables helped to better identify the sickest cystic fibrosis and chronic obstructive pulmonary disease patients awaiting transplants.