Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis

This study suggests that reduced gamma-aminobutyric acid levels reflect pathological abnormalities that may play a role in determining physical disability. These abnormalities may include decreases in the pre- and postsynaptic components of gamma-aminobutyric acid neurotransmission and in the density of inhibitory neurons. Additionally, the reduced gamma-aminobutyric acid concentration may contribute to the neurodegenerative process, resulting in increased firing of axons, with consequent increased energy demands, which may lead to neuroaxonal degeneration and loss of the compensatory mechanisms that maintain motor function. This study supports the idea that modulation of gamma-aminobutyric acid neurotransmission may be an important target for neuroprotection in multiple sclerosis.
See De Stefano and Giorgio (doi:10.1093/brain/awv213) for a scientific commentary on this article.

Source: Brain - August 24, 2015 Category: Neurology Authors: Cawley, N., Solanky, B. S., Muhlert, N., Tur, C., Edden, R. A. E., Wheeler-Kingshott, C. A. M., Miller, D. H., Thompson, A. J., Ciccarelli, O. Tags: Multiple Sclerosis/Neuroinflammation Original Articles Source Type: research