Abstract 916: The molecular landscape of colorectal cancer cell lines unveils clinically actionable targets

In conclusion our data suggest that overexpression of TK outliers drives primary resistance to EGFR blockade, and could be used to identify patients unlikely to respond to cetuximab or panitumumab. Moreover, the approach described here can be used to pinpoint colorectal cancers with exquisite dependencies to individual kinases for which clinically approved drugs are already available.Citation Format: Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Giorgio Corti, Emanuele Valtorta, Silvio Veronese, Marco Beccuti, Francesca Cordero, Federica Di Nicolantonio, Enzo Medico, Alberto Bardelli. The molecular landscape of colorectal cancer cell lines unveils clinically actionable targets. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 916. doi:10.1158/1538-7445.AM2015-916

Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Russo, M., Picco, G., Cancelliere, C., Corti, G., Valtorta, E., Veronese, S., Beccuti, M., Cordero, F., Di Nicolantonio, F., Medico, E., Bardelli, A. Tags: Prevention Research Source Type: research