[RETROSPECTIVE] Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm

Modern tuberculosis (TB) chemotherapy is widely viewed as a crowning triumph of anti-infectives research. However, only one new TB drug has entered clinical practice in the past 40 years while drug resistance threatens to further destabilize the pandemic. Here, we review a brief history of TB drug development, focusing on the evolution of mechanism(s)-of-action studies and key conceptual barriers to rational, mechanism-based drugs.

Source: Cold Spring Harbor perspectives in medicine - August 3, 2015 Category: Research Authors: Chakraborty, S., Rhee, K. Y. Tags: Tuberculosis RETROSPECTIVE Source Type: research