Systematic Review by Multivariate Meta-analyses on the Possible Role of Tumor Necrosis Factor-α Gene Polymorphisms in Association with Ischemic Stroke

In conclusion, the present systematic review and meta-analysis support a prominent role of the TNF-α −238G/A polymorphism in the risk of ischemic stroke in Asian adults only, but do not support the role of −308G/A, −857C/T, −1031T/C, −244G/A, −367G/A, −646G/A, −806C/T, −863C/A, and +448G/A in the risk of ischemic stroke. The current evidence warrants further studies with high quality and large sample size to confirm.

http://link.springer.com/10.1007/s12017-015-8365-7

Source: NeuroMolecular Medicine - July 31, 2015 Category: Neurology Source Type: research