Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27
Conclusions:
The data demonstrates that PHD3 can drive cell cycle entry at the G1/S transition through decreasing the half-life of p27 that occurs by attenuating p27S10 phosphorylation.
Source: Molecular Cancer - Category: Cancer & Oncology Authors: Heidi HögelPetra MiikkulainenLucia BinoPanu Jaakkola Source Type: research