The Zinc Ion Chelating Agent TPEN Attenuates Neuronal Death/apoptosis Caused by Hypoxia/ischemia Via Mediating the Pathophysiological Cascade Including Excitotoxicity, Oxidative Stress, and Inflammation.

CONCLUSIONS: Zn(2+) is involved in neural cell apoptosis and/or death caused by hypoxia/ischemia via mediating excitotoxicity, oxidative stress, and inflammation.
PMID: 26190227 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - July 20, 2015 Category: Neuroscience Authors: Wang WM, Liu Z, Liu AJ, Wang YX, Wang HG, An D, Heng B, Xie LH, Duan JL, Liu YQ Tags: CNS Neurosci Ther Source Type: research