Silencing of protease‐activated receptors attenuates synovitis and cartilage damage following a joint bleed in haemophilic mice

ConclusionThis study demonstrates that synovial and chondrocyte PAR expression is altered upon a joint bleed, and that treatment with PAR1–4 siRNA attenuates synovitis and plasmin‐induced cartilage damage.

Source: Haemophilia - July 1, 2015 Category: Hematology Authors: L. Nieuwenhuizen, R. E. G. Schutgens, K. Coeleveld, S. C. Mastbergen, R. M. Schiffelers, G. Roosendaal, D. H. Biesma, F. P. J. G. Lafeber Tags: Original Article Source Type: research