Intravenous immunoglobulin in patients with acquired Von Willebrand syndrome: A single referral centre experience
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - November 21, 2018 Category: Hematology Authors: Julien Bertolino, Manal Ibrahim, Julie Seguier, Elodie Masson, Emmanuelle Bernit, Veronique Veit, Mikael Ebbo, Jean ‐Robert Harlé, Hajar Khibri, Catherine Pouymayou, Pierre‐Emmanuel Morange, Nicolas Schleinitz Tags: LETTER TO THE EDITOR Source Type: research

Samuel Armstrong Lane's first successful treatment of haemophilia with blood transfusion in 1840: Could this also be the first successful bypassing therapy?
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - November 21, 2018 Category: Hematology Authors: Man ‐Chiu Poon, Robert T. Card Tags: LETTER TO THE EDITOR Source Type: research

Utility valuation of health states for haemophilia and related complications in Europe and in the United States
ConclusionsThis study underlines the value that the French, Italian, German, Swedish, United States and UK populations ascribe to the avoidance of disease progression in haemophilia without inhibitors. Improved treatment options hold a potential for important benefits to haemophilia patients. (Source: Haemophilia)
Source: Haemophilia - November 21, 2018 Category: Hematology Authors: Christina S. Hoxer, Marek Zak, Khadra Benmedjahed, J érémy Lambert Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
Haemophilia, Volume 24, Issue S7, Page 1-4, November 2018. (Source: Haemophilia)
Source: Haemophilia - November 20, 2018 Category: Hematology Tags: ISSUE INFORMATION Source Type: research

Ranges and drivers of risk associated with sports and recreational activities in people with haemophilia: results of the Activity ‐Intensity‐Risk Consensus Survey of US physical therapists
ConclusionsThese data provide a framework for discussion with patients/families, recognizing how certain activities may be modified to decrease risk, and identifying activities with nonmodifiable inherent risks. (Source: Haemophilia)
Source: Haemophilia - November 20, 2018 Category: Hematology Authors: Grace Hernandez, Kimberly Baumann, Susan Knight, Heidi Purrington, Marc Gilgannon, Jennifer Newman, Patricia Tobase, Sheba Mathew, David L. Cooper Tags: ORIGINAL ARTICLE Source Type: research

Joint status in Spanish haemophilia B patients assessed using the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD ‐US) score
ConclusionJoint status of HB patients in Spain is influenced by severity and treatment modality, related to the development of arthropathy, which appears prevalent in OD patients with severe HB. Routine assessment with an imaging tool such as ultrasound and HEAD ‐US system may help to improve joint health by personalizing and adjusting treatment in this population. (Source: Haemophilia)
Source: Haemophilia - November 16, 2018 Category: Hematology Authors: Victor Jim énez‐Yuste, María Teresa Álvarez‐Román, Mónica Martín‐Salces, Hortensia De la Corte‐Rodríguez, Carmen Altisent, Rafael Parra, Ramiro Núñez, Rosario Pérez, Faustino García‐Candel, Santiago Bonanad, Felipe Querol, Tags: ORIGINAL ARTICLE Source Type: research

Emicizumab: Review of the literature and critical appraisal
ConclusionThe principal advantage of emicizumab is subcutaneous administration and effectiveness irrespective of the presence of inhibitors. Emicizumab could conceivably represent a new epoch in the treatment of people with haemophilia A. (Source: Haemophilia)
Source: Haemophilia - November 15, 2018 Category: Hematology Authors: E. Carlos Rodriguez ‐Merchan, Leonard A. Valentino Tags: REVIEW ARTICLE Source Type: research

Whole exome sequencing in the diagnostic workup of patients with a bleeding diathesis
ConclusionBased on our findings, we conclude that performing WES at the end of the diagnostic trajectory can be of additive value to explain the complete bleeding phenotype in patients without a definite diagnosis after conventional laboratory tests. Discovery of combinations of (novel) genes that predispose to bleeding will increase the diagnostic yield in patients with an unexplained bleeding diathesis. (Source: Haemophilia)
Source: Haemophilia - November 15, 2018 Category: Hematology Authors: Joline L. Saes, Annet Simons, Sonja A. de Munnik, Marten R. Nijziel, Nicole M. A. Blijlevens, Marjolijn C. Jongmans, Bert A. van der Reijden, Yolba Smit, Paul P. Brons, Waander L. van Heerde, Saskia E. M. Schols Tags: ORIGINAL ARTICLE Source Type: research

Does haemophilia slow down the development of liver fibrosis?
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - November 14, 2018 Category: Hematology Authors: Marie ‐Astrid van Dievoet, Isabelle Leclercq, Cedric Hermans, Catherine Lambert, Yves Horsmans, Marc Jacquemin, Stéphane Eeckhoudt Tags: LETTER TO THE EDITOR Source Type: research

Measurement of joint health in persons with haemophilia: A systematic review of the measurement properties of haemophilia ‐specific instruments
ConclusionOnly patchy evidence is available on the quality of measurement properties of all haemophilia ‐specific joint health scores. Although significant gaps in the evidence for all instruments remain, measurement properties of the HJHS were most extensively studied and show no drawbacks for use in clinical practice. This review forms the basis for further research aimed at the assessment of meas urement properties of measurement tools to assess joint health. (Source: Haemophilia)
Source: Haemophilia - November 14, 2018 Category: Hematology Authors: Samantha C. Gouw, Merel A. Timmer, Alok Srivastava, Piet Kleijn, Pamela Hilliard, Marjolein Peters, Victor Blanchette, Kathelijn Fischer Tags: ORIGINAL ARTICLE Source Type: research

Health ‐related quality of life in paediatric haemophilia B patients treated with rIX‐FP
ConclusionProphylaxis with rIX ‐FP led to substantial improvements in HRQoL in paediatric patients and treatment satisfaction in caregivers. (Source: Haemophilia)
Source: Haemophilia - November 14, 2018 Category: Hematology Authors: Sylvia von Mackensen, Jinesh Shah, Wilfried Seifert, Gili Kenet Tags: ORIGINAL ARTICLE Source Type: research

The effect of emicizumab prophylaxis on health ‐related outcomes in persons with haemophilia A with inhibitors: HAVEN 1 Study
ConclusionsIn PwHA with inhibitors, emicizumab prophylaxis was associated with substantial and meaningful improvements in health ‐related outcomes. (Source: Haemophilia)
Source: Haemophilia - November 14, 2018 Category: Hematology Authors: Johannes Oldenburg, Johnny N. Mahlangu, Willem Bujan, Peter Trask, Michael U. Callaghan, Guy Young, Elina Asikanius, Flora Peyvandi, Elena Santagostino, Rebecca Kruse ‐Jarres, Claude Negrier, Craig Kessler, Jin Xu, Jerzy Windyga, Midori Sh Tags: ORIGINAL ARTICLE Source Type: research

Prevalence of FVIII inhibitors in severe haemophilia A patients: Effect of treatment and genetic factors in an Indian population
ConclusionThe overall prevalence of inhibitors in patients with severe haemophilia A is similar to that reported among patients receiving regular replacement therapy. The data from this study, limited by its retrospective and cross ‐sectional study design, would suggest that genetic rather than environmental are more likely to impact the development of inhibitors. (Source: Haemophilia)
Source: Haemophilia - November 14, 2018 Category: Hematology Authors: Sachin David, Sukesh C. Nair, G. Surender Singh, Ansu Abu Alex, Saravanan Ganesan, Hamenth Kumar Palani, Nithya Balasundaram, Kavitha M. Lakshmi, Aditi Joshi, S. Kannan, Anu Korula, Fouzia Nambiatheyil Aboobacker, Aby Abraham, Biju George, S Tags: ORIGINAL ARTICLE Source Type: research

Sports participation and physical activity in patients with von Willebrand disease
ConclusionThe majority of VWD patients participated in sports. Patients with type 3 VWD, a history of joint bleeds and a more severe bleeding phenotype frequently experienced limitations in sports participation and physical activities during daily life. (Source: Haemophilia)
Source: Haemophilia - November 14, 2018 Category: Hematology Authors: Ferdows Atiq, Eveline P. Mauser ‐Bunschoten, Jeroen Eikenboom, Karin P. M. van Galen, Karina Meijer, Joke de Meris, Marjon H. Cnossen, Erick A. M. Beckers, Britta A. P. Laros‐van Gorkom, Laurens Nieuwenhuizen, Johanna G. van der Bom, Karin Tags: ORIGINAL ARTICLE Source Type: research

Concizumab restores thrombin generation potential in patients with haemophilia: Pharmacokinetic/pharmacodynamic modelling results of concizumab phase 1/1b data
ConclusionConcizumab phase 2 trials will target an exposure ≥100 ng/mL, with a once‐daily regimen. (Source: Haemophilia)
Source: Haemophilia - November 8, 2018 Category: Hematology Authors: Hermann Eichler, Pantep Angchaisuksiri, Kaan Kavakli, Paul Knoebl, Jerzy Windyga, Victor Jim énez‐Yuste, Philip Harder Delff, Pratima Chowdary Tags: ORIGINAL ARTICLE Source Type: research

Severe acquired von Willebrand syndrome secondary to systemic lupus erythematosus
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - November 8, 2018 Category: Hematology Authors: Francesca Stufano, Luciano Baronciani, Eugenia Biguzzi, Giovanna Cozzi, Paola Colpani, Marta Chisini, Flora Peyvandi Tags: LETTER TO THE EDITOR Source Type: research

Treatment regimens and outcomes in severe and moderate haemophilia A in the UK: The THUNDER study
We report 1810 patients with SHA and 864 with MHA. Prophylaxis was used in 94.9% (n  = 130/137) of HT‐compliant children
Source: Haemophilia - November 8, 2018 Category: Hematology Authors: Martin J. Scott, Hua Xiang, Daniel P. Hart, Benedict Palmer, Peter W. Collins, David Stephensen, Camelia S. Sima, Charles R. M. Hay Tags: ORIGINAL ARTICLE Source Type: research

Long ‐term safety and efficacy of turoctocog alfa in prophylaxis and treatment of bleeding episodes in severe haemophilia A: Final results from the guardian 2 extension trial
ConclusionExtended use of turoctocog alfa is safe and effective for prevention and treatment of bleeding episodes in previously treated patients with haemophilia A across all ages. (Source: Haemophilia)
Source: Haemophilia - November 6, 2018 Category: Hematology Authors: Steven R. Lentz, Dragana Janic, Kaan Kavakli, Predrag Miljic, Johannes Oldenburg, Margareth C. Ozelo, Elena Santagostino, Takashi Suzuki, Silva Zupancic Šalek, Lars Korsholm, Irina Matytsina, Andreas Tiede Tags: ORIGINAL ARTICLE Source Type: research

The prevalence and burden of hand and wrist bleeds in von Willebrand disease
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - November 5, 2018 Category: Hematology Authors: D ésirée van Deukeren, Eveline P. Mauser‐Bunschoten, Roger E. G. Schutgens, Jeroen Eikenboom, Karina Meijer, Karin Fijnvandraat, Britta A. P. Laros‐van Gorkom, Marjon Cnossen, Joke de Meris, Johanna G. van der Bom, Frank W. G. Leebeek, Ka Source Type: research

Continuous infusion of simoctocog alfa in haemophilia A patients undergoing surgeries
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - November 5, 2018 Category: Hematology Authors: P ål Andre Holme, Geir E. Tjønnfjord Source Type: research

Assessment of tensile mechanical properties of the Achilles tendon in adult patients with haemophilic arthropathy. Reproducibility study
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - October 30, 2018 Category: Hematology Authors: Carlos Cruz ‐Montecinos, Sofía Pérez‐Alenda, Felipe Contreras‐Sepúlveda, Felipe Querol, Mauricio Cerda, Huub Maas Source Type: research

Thromboelastography and thrombin generation assay in inherited afibrinogenemia
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - October 22, 2018 Category: Hematology Authors: Guy Aaron Young, Roxana Carmona, Viridiana Cano Garcia Source Type: research

Improving access to haemophilia therapies —Beyond humanitarian aid
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - October 12, 2018 Category: Hematology Authors: Albert Farrugia, Giancarlo Liumbruno, Gabriele Calizzani, Fabio Candura, Samantha Profili, Josephine Cassar Source Type: research

Use of two complementary new molecular techniques, next ‐generation sequencing and droplet digital PCR, for diagnosis of an F8 gene deletion and subsequent carrier analysis in a family with haemophilia A: A Case Report
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - October 9, 2018 Category: Hematology Authors: Priyanka Gangodkar, Shatakshi Ranade, Siddharth Anand, Ashwini Bapat, Kavita Khatod, Parth Shah, Meenal Agarwal, Nikhil Phadke Source Type: research

Bleeding events and safety outcomes in persons with haemophilia A with inhibitors: A prospective, multi ‐centre, non‐interventional study
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - October 8, 2018 Category: Hematology Authors: Johnny Mahlangu, Johannes Oldenburg, Michael U. Callaghan, Midori Shima, Elena Santagostino, Maggie Moore, Michael Recht, Claudia Garcia, Renchi Yang, Michaela Lehle, Harrison Macharia, Elina Asikanius, Gallia G. Levy, Rebecca Kruse ‐Jarres Source Type: research

Investigating the relationship between the HJHS and HAL in routine clinical practice: A retrospective review
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - October 8, 2018 Category: Hematology Authors: Paul McLaughlin, Richard Morris, Pratima Chowdary Source Type: research

Usefulness of bone microarchitectural and geometric DXA ‐derived parameters in haemophilic patients
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - October 1, 2018 Category: Hematology Authors: Fabio Massimo Ulivieri, Giulia Antonella Angela Rebagliati, Luca Petruccio Piodi, Luigi Piero Solimeno, Gianluigi Pasta, Elena Boccalandro, Maria Rosaria Fasulo, Maria Elisa Mancuso, Elena Santagostino Source Type: research

Association between ABO blood group and bleeding phenotype in patients with mild rare bleeding disorders
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - September 27, 2018 Category: Hematology Authors: Luca Spiezia, Elena Campello, Giacomo Turatti, Chiara Simion, Mariangela Fadin, Sabrina Gavasso, Graziella Saggiorato, Francesca Sartorello, Patrizia Zerbinati, Paolo Simioni Source Type: research

Once ‐weekly prophylaxis with 40 IU/kg nonacog beta pegol (N9‐GP) achieves trough levels of > 15% in patients with haemophilia B: Pooled data from the paradigm ™ trials
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - September 24, 2018 Category: Hematology Authors: Johannes Oldenburg, Manuel Carcao, Steven R. Lentz, Johnny Mahlangu, Maria Elisa Mancuso, Tadashi Matsushita, Claude N égrier, Wan Hui Ong Clausen, Silke Ehrenforth, Guy Young Source Type: research

Impact of intermediate ‐dose prophylaxis on progression of haemarthropathy in patients with severe haemophilia A: A 10‐year, single‐centre experience in Korea
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - September 24, 2018 Category: Hematology Authors: Ju Y. Kim, Da J. Lee, Tong J. Chun, Chur W. You Source Type: research

Issue Information
Haemophilia,Volume 24, Issue 5, Page 685-689, September 2018. (Source: Haemophilia)
Source: Haemophilia - September 24, 2018 Category: Hematology Source Type: research

Instructions for Authors
Haemophilia,Volume 24, Issue 5, Page 833-833, September 2018. (Source: Haemophilia)
Source: Haemophilia - September 24, 2018 Category: Hematology Source Type: research

Utility of a screening tool for haemostatic defects in a multicentre cohort of adolescents with heavy menstrual bleeding
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - September 12, 2018 Category: Hematology Authors: Ayesha Zia , Joseph Stanek , Myra Christian ‐Rancy , Sanjay P. Ahuja , Stephanie Savelli , Sarah H. O’Brien Source Type: research

UK Haemophilia Centre Doctors ’ Organisation guidance on the use of extended‐half‐life coagulation factor concentrates in routine clinical practice: Report of a meeting on their adoption by Belgian haemophilia treaters
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - September 5, 2018 Category: Hematology Authors: Cedric Hermans , An Van Damme , Gerry Dolan , Philip Maes , Kathelijne Peerlinck Source Type: research

Orthotopic liver transplantation for haemophilia A may not always lead to a phenotypic cure of haemophilia A: A case report
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - September 3, 2018 Category: Hematology Authors: Yuji Suzuki , Keisuke Kakisaka , Tomoko Matsumoto , Keiji Nogami , Hirokatsu Katagiri , Takeshi Takahara , Yasuhiro Takikawa Source Type: research

Identification of a homozygous missense mutation (p.Cys379Gly) in the D1 domain of von Willebrand factor propeptide in a family with type 2A (IIC) von Willebrand disease
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - September 3, 2018 Category: Hematology Authors: Toshio Shigekiyo , Kengo Udaka , Etsuko Sekimoto , Hironobu Shibata , Shuji Ozaki , Yukio Higuchi , Masanori Matsumoto Source Type: research

Congenital coagulation factor X deficiency: Genetic analysis of five patients and functional characterization of mutant factor X proteins
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - August 28, 2018 Category: Hematology Authors: Satomi Nagaya , Masashi Akiyama , Morika Murakami , Akiko Sekiya , Hidesaku Asakura , Eriko Morishita Source Type: research

Challenges in diagnosis and management of acquired factor XIII (FXIII) inhibitors
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - August 24, 2018 Category: Hematology Authors: Joan D. Beckman , Raj S. Kasthuri , Alisa S. Wolberg , Alice D. Ma Source Type: research

Positioning extended half ‐life concentrates for future use: a practical proposal
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - August 24, 2018 Category: Hematology Authors: Angelique Nederlof , Ron A. A. Math ôt , Frank W. G. Leebeek , Karin Fijnvandraat , Kathelijn Fischer , Marjon H. Cnossen , on behalf of Source Type: research

Haemophilia care in Latin America: Assessment and perspectives
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - August 24, 2018 Category: Hematology Authors: Apsara Boadas , Margareth C. Ozelo , Maria Solano , Adolfina Berges , Arlette Ruiz ‐Saez , Adriana Linares , José Luis Lamas , Rafael Aparicio , Luis Aversa , Alejandra Baques , Armando Estrada , Misael Herrejon , Ana Mancia , Source Type: research

Issue Information
Haemophilia,Volume 24, Issue 4, Page 505-509, July 2018. (Source: Haemophilia)
Source: Haemophilia - August 24, 2018 Category: Hematology Source Type: research

Instructions for Authors
Haemophilia,Volume 24, Issue 4, Page 684-684, July 2018. (Source: Haemophilia)
Source: Haemophilia - August 24, 2018 Category: Hematology Source Type: research

Defining patient value in haemophilia care
Haemophilia,Volume 24, Issue 4, Page 516-518, July 2018. (Source: Haemophilia)
Source: Haemophilia - August 24, 2018 Category: Hematology Authors: E. C. van Balen , S. C. Gouw , J. A. Hazelzet , J. G. van der Bom , M. H. Cnossen Source Type: research

A changing haemophilia world: Opportunities and challenges for the Haemophilia journal
Haemophilia,Volume 24, Issue 4, Page 514-515, July 2018. (Source: Haemophilia)
Source: Haemophilia - August 24, 2018 Category: Hematology Authors: Cedric Hermans Source Type: research

New Editor ‐in‐Chief for Haemophilia!
Haemophilia,Volume 24, Issue 4, Page 513-513, July 2018. (Source: Haemophilia)
Source: Haemophilia - August 24, 2018 Category: Hematology Source Type: research

Efficacy and safety of low ‐dose prophylaxis of highly purified plasma‐derived factor VIII concentrate produced by the National Blood Centre, Thai Red Cross Society
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - August 17, 2018 Category: Hematology Authors: Ampaiwan Chuansumrit , Darintr Sosothikul , Rungrote Natesirinilkul , Yujinda Lektrakul , Ubonwon Charoonruangrit , , Kanhati Chiengthon , Kwannut Srikala , Pakawan Wongwerawattanakoon , Praguywan Kadegasem , Pi Source Type: research

Retrospective review of Acquired Haemophilia A from the largest Canadian Haemophilia treatment centre
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - August 16, 2018 Category: Hematology Authors: Jai P. Jayakar , Natalya O'Neill , Marie Yan , Rosane Nisenbaum , Marie B. Garvey , Jerome Teitel , Michelle Sholzberg Source Type: research

Pain assessment and management in haemophilia: A survey among Italian patients and specialist physicians
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - August 16, 2018 Category: Hematology Authors: AnnaritaTagliaferri , MassimoFranchini , Gianna F.Rivolta , StefaniaFarace , GabrieleQuintavalle , AntonioCoppola , on behalf of , Maria CristinaArbasi, Anna BrigidaAru, ErminiaBaldacci, ElisaBonetti, IsabellaCantori, Anna MariaCerbone, Anton Source Type: research

Rate and appropriateness of polypharmacy in older patients with hemophilia compared with age ‐matched controls
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - August 16, 2018 Category: Hematology Authors: Pier Mannuccio Mannucci , Alessandro Nobili , Emanuela Marchesini , Emily Oliovecchio , Laura Cortesi , Antonio Coppola , Elena Santagostino , Paolo Radossi , Giancarlo Castaman , Lelia Valdr è , Cristina Santoro , Source Type: research

Evaluating the thrombin generation profiles of four different rFVIII products in FVIII ‐deficient plasma using FIXa and FXIa activation
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - August 16, 2018 Category: Hematology Authors: Donald F. Brophy , Erika J. Martin , Marisa Ninivaggi , Bassem M. Mohammed , John C. Barrett , Janice Kuhn , Melinda E. Nolte , Emily K. Waters , Mirella Ezban Source Type: research