Cardiovascular disease ‐related hospitalization and mortality among persons with von Willebrand disease: A nationwide register study in Sweden
ConclusionsIn this nationwide, long ‐term register study with individually matched controls, we have been able to show that persons with VWD have a higher hospitalization rate due to CVD events. However, the mortality rates appear lower than in the control population. The latter finding is consistent with previous studies and indica tes a protective effect of the clotting factor deficiency inherited with VWD. (Source: Haemophilia)
Source: Haemophilia - November 23, 2018 Category: Hematology Authors: Elena Holm,
Mehdi Osooli,
Katarina Steen Carlsson,
Erik Berntorp Tags: ORIGINAL ARTICLE Source Type: research
A novel approach to immune tolerance induction in haemophilia A with factor VIII inhibitor
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - November 23, 2018 Category: Hematology Authors: Courtney D. Thornburg,
Jonathan Ducore Tags: LETTER TO THE EDITOR Source Type: research
Thromboelastometry profiles after “in vitro” addition of a new plasma‐derived factor V concentrate to whole blood from parahaemophilia patients
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - November 23, 2018 Category: Hematology Authors: Cristiana Bulato,
Claudia Maria Radu,
Luca Spiezia,
Elena Campello,
Giovanni Barillari,
Paola Pradella,
Paolo Simioni Tags: LETTER TO THE EDITOR Source Type: research
Intravenous immunoglobulin in patients with acquired Von Willebrand syndrome: A single referral centre experience
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - November 21, 2018 Category: Hematology Authors: Julien Bertolino,
Manal Ibrahim,
Julie Seguier,
Elodie Masson,
Emmanuelle Bernit,
Veronique Veit,
Mikael Ebbo,
Jean ‐Robert Harlé,
Hajar Khibri,
Catherine Pouymayou,
Pierre‐Emmanuel Morange,
Nicolas Schleinitz Tags: LETTER TO THE EDITOR Source Type: research
Samuel Armstrong Lane's first successful treatment of haemophilia with blood transfusion in 1840: Could this also be the first successful bypassing therapy?
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - November 21, 2018 Category: Hematology Authors: Man ‐Chiu Poon,
Robert T. Card Tags: LETTER TO THE EDITOR Source Type: research
Utility valuation of health states for haemophilia and related complications in Europe and in the United States
ConclusionsThis study underlines the value that the French, Italian, German, Swedish, United States and UK populations ascribe to the avoidance of disease progression in haemophilia without inhibitors. Improved treatment options hold a potential for important benefits to haemophilia patients. (Source: Haemophilia)
Source: Haemophilia - November 21, 2018 Category: Hematology Authors: Christina S. Hoxer,
Marek Zak,
Khadra Benmedjahed,
J érémy Lambert Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
Haemophilia, Volume 24, Issue S7, Page 1-4, November 2018. (Source: Haemophilia)
Source: Haemophilia - November 20, 2018 Category: Hematology Tags: ISSUE INFORMATION Source Type: research
Ranges and drivers of risk associated with sports and recreational activities in people with haemophilia: results of the Activity ‐Intensity‐Risk Consensus Survey of US physical therapists
ConclusionsThese data provide a framework for discussion with patients/families, recognizing how certain activities may be modified to decrease risk, and identifying activities with nonmodifiable inherent risks. (Source: Haemophilia)
Source: Haemophilia - November 20, 2018 Category: Hematology Authors: Grace Hernandez,
Kimberly Baumann,
Susan Knight,
Heidi Purrington,
Marc Gilgannon,
Jennifer Newman,
Patricia Tobase,
Sheba Mathew,
David L. Cooper Tags: ORIGINAL ARTICLE Source Type: research
Joint status in Spanish haemophilia B patients assessed using the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD ‐US) score
ConclusionJoint status of HB patients in Spain is influenced by severity and treatment modality, related to the development of arthropathy, which appears prevalent in OD patients with severe HB. Routine assessment with an imaging tool such as ultrasound and HEAD ‐US system may help to improve joint health by personalizing and adjusting treatment in this population. (Source: Haemophilia)
Source: Haemophilia - November 16, 2018 Category: Hematology Authors: Victor Jim énez‐Yuste,
María Teresa Álvarez‐Román,
Mónica Martín‐Salces,
Hortensia De la Corte‐Rodríguez,
Carmen Altisent,
Rafael Parra,
Ramiro Núñez,
Rosario Pérez,
Faustino García‐Candel,
Santiago Bonanad,
Felipe Querol,
Tags: ORIGINAL ARTICLE Source Type: research
Emicizumab: Review of the literature and critical appraisal
ConclusionThe principal advantage of emicizumab is subcutaneous administration and effectiveness irrespective of the presence of inhibitors. Emicizumab could conceivably represent a new epoch in the treatment of people with haemophilia A. (Source: Haemophilia)
Source: Haemophilia - November 15, 2018 Category: Hematology Authors: E. Carlos Rodriguez ‐Merchan,
Leonard A. Valentino Tags: REVIEW ARTICLE Source Type: research
Whole exome sequencing in the diagnostic workup of patients with a bleeding diathesis
ConclusionBased on our findings, we conclude that performing WES at the end of the diagnostic trajectory can be of additive value to explain the complete bleeding phenotype in patients without a definite diagnosis after conventional laboratory tests. Discovery of combinations of (novel) genes that predispose to bleeding will increase the diagnostic yield in patients with an unexplained bleeding diathesis. (Source: Haemophilia)
Source: Haemophilia - November 15, 2018 Category: Hematology Authors: Joline L. Saes,
Annet Simons,
Sonja A. de Munnik,
Marten R. Nijziel,
Nicole M. A. Blijlevens,
Marjolijn C. Jongmans,
Bert A. van der Reijden,
Yolba Smit,
Paul P. Brons,
Waander L. van Heerde,
Saskia E. M. Schols Tags: ORIGINAL ARTICLE Source Type: research
Does haemophilia slow down the development of liver fibrosis?
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - November 14, 2018 Category: Hematology Authors: Marie ‐Astrid van Dievoet,
Isabelle Leclercq,
Cedric Hermans,
Catherine Lambert,
Yves Horsmans,
Marc Jacquemin,
Stéphane Eeckhoudt Tags: LETTER TO THE EDITOR Source Type: research
Measurement of joint health in persons with haemophilia: A systematic review of the measurement properties of haemophilia ‐specific instruments
ConclusionOnly patchy evidence is available on the quality of measurement properties of all haemophilia ‐specific joint health scores. Although significant gaps in the evidence for all instruments remain, measurement properties of the HJHS were most extensively studied and show no drawbacks for use in clinical practice. This review forms the basis for further research aimed at the assessment of meas urement properties of measurement tools to assess joint health. (Source: Haemophilia)
Source: Haemophilia - November 14, 2018 Category: Hematology Authors: Samantha C. Gouw,
Merel A. Timmer,
Alok Srivastava,
Piet Kleijn,
Pamela Hilliard,
Marjolein Peters,
Victor Blanchette,
Kathelijn Fischer Tags: ORIGINAL ARTICLE Source Type: research
Health ‐related quality of life in paediatric haemophilia B patients treated with rIX‐FP
ConclusionProphylaxis with rIX ‐FP led to substantial improvements in HRQoL in paediatric patients and treatment satisfaction in caregivers. (Source: Haemophilia)
Source: Haemophilia - November 14, 2018 Category: Hematology Authors: Sylvia von Mackensen,
Jinesh Shah,
Wilfried Seifert,
Gili Kenet Tags: ORIGINAL ARTICLE Source Type: research
The effect of emicizumab prophylaxis on health ‐related outcomes in persons with haemophilia A with inhibitors: HAVEN 1 Study
ConclusionsIn PwHA with inhibitors, emicizumab prophylaxis was associated with substantial and meaningful improvements in health ‐related outcomes. (Source: Haemophilia)
Source: Haemophilia - November 14, 2018 Category: Hematology Authors: Johannes Oldenburg,
Johnny N. Mahlangu,
Willem Bujan,
Peter Trask,
Michael U. Callaghan,
Guy Young,
Elina Asikanius,
Flora Peyvandi,
Elena Santagostino,
Rebecca Kruse ‐Jarres,
Claude Negrier,
Craig Kessler,
Jin Xu,
Jerzy Windyga,
Midori Sh Tags: ORIGINAL ARTICLE Source Type: research
