ISMRM: MRI useful in predicting tumor response in breast cancer patients

Integrating MR elastography (MRE) in a routine MRI scanner and combining it with dynamic contrast-enhanced MRI (DCE-MRI) could predict complete pathological response at the end of neoadjuvant chemotherapy in breast cancer patients, according to a presentation at the International Society for Magnetic Resonance in Medicine (ISMRM) annual meeting. Researchers led by Aish Sinha, MBBS, from King’s College London in England demonstrated how combining DCE-MRI with MRE achieved high sensitivity and specificity in predicting complete pathological response. “Quantifying biomechanics throughout chemotherapy via MRE in conjunction with DCE-MRI in breast cancer patients undergoing primary chemotherapy yields more accurate results in predicting complete pathological response than current international imaging gold standard methods,” Sinha said. DCE-MRI is the gold standard for monitoring tumor response in breast cancer patients who undergo neoadjuvant chemotherapy, Sinha highlighted. However, he added that there is a need to identify alternative, non-invasive imaging biomarkers to find tissue alterations related to tumor response mechanisms. The researchers studied whether biomechanics quantified over time with MRE can identify complete pathological response in patients undergoing chemotherapy, as well as predict response at an earlier time point throughout chemotherapy. They integrated MRE into a biopsy coil (Siemens Healthineers) for integration of data gathering within stand...
Source: AuntMinnie.com Headlines - Category: Radiology Authors: Tags: ISMRM 2024 Source Type: news