Targeted Demethylation of FOXP3-TSDR Enhances the Suppressive Capacity of STAT6-deficient Inducible T Regulatory Cells

In conclusion, the deactivation of STAT6 and TSDR-targeted demethylation via CRISPR-T ET1 is sufficient to induce iTregs with heightened stability and increased suppressive capacity, offering potential applications against inflammatory and autoimmune diseases.
Source: Inflammation - Category: Allergy & Immunology Source Type: research