IL-22 is increased in hospitalized patients with COVID-19 and associates with cardiac involvement

Dear Editor, we read with great interest the paper by Marjaneh et al. using whole blood transcriptome analyses to show that IL-22 was one of the genes negatively correlated with upper respiratory tract viral load in COVID-19 patients.1 IL-22 is produced by hematopoietic cells, however, its receptor, composed of IL-22R1 and IL-10R2, is mainly expressed on fibroblast and endothelial cells. IL-22 is therefore an important communication route between immune cells and structural cells such as within the respiratory tract, shown to have both tissue protective and pro-inflammatory effects during infections2; and thus of interest with regards to COVID-19.

Source: Journal of Infection - May 6, 2024 Category: Infectious Diseases Authors: Bente Halvorsen, Hans-Kittil Viermyr, Thor Ueland, Ellen Lund Sagen, Annika E Michelsen, Vigdis Bjerkeli, The Nor-Solidarity Study Group, Anders Aune Tveita, Katerina Nezvalova Henriksen, Trine K åsine, Anne Ma Dyrhol-Riise, Marius Trøseid, Tuva Børres Source Type: research