Points to consider regarding the use and implementation of virtual controls in nonclinical general toxicology studies
Regul Toxicol Pharmacol. 2024 Apr 27;150:105632. doi: 10.1016/j.yrtph.2024.105632. Online ahead of print.ABSTRACTThe replacement of a proportion of concurrent controls by virtual controls in nonclinical safety studies has gained traction over the last few years. This is supported by foundational work, encouraged by regulators, and aligned with societal expectations regarding the use of animals in research. This paper provides an overview of the points to consider for any institution on the verge of implementing this concept, with emphasis given on database creation, risks, and discipline-specific perspectives.PMID:38679316 | DOI:10.1016/j.yrtph.2024.105632
Source: Regulatory Toxicology and Pharmacology : RTP - Category: Toxicology Authors: Xavier Palazzi Lennart T Anger Theresa Boulineau Armelle Grevot Magali Guffroy Kristin Henson Natalie Hoepp Matt Jacobsen Vijay P Kale John Kreeger Joan H Lane Dingzhou Li Wolfgang Muster Brianna Paisley Lila Ramaiah Nicola Robertson Valerie Shultz Thomas Source Type: research