The role of lncFABP4 in modulating adipogenic differentiation in buffalo intramuscular preadipocytes

In this study, we identified and characterized a lncRNA, lncFABP4, which is transcribed from the antisense strand of fatty acid-binding protein 4 (FABP4). lncFABP4 inhibited cell proliferation in buffalo intramuscular preadipocytes. Moreover, lncFABP4 significantly increased intramuscular preadipocyte differentiation, as indicated by an increase in the expression of the adipogenic markers peroxisome proliferator-activated receptor gamma (PPARG), CCAAT enhancer binding protein alpha (C/EBP α), andFABP4. Mechanistically, lncFABP4 was found to have the potential to regulate downstream gene expression by participating in protein –protein interaction pathways. These findings contribute to further understanding of the intricate mechanisms through which lncRNAs modulate intramuscular adipogenesis in buffaloes.

Source: Animal Science Journal - May 5, 2024 Category: Zoology Authors: Ruirui Li, Ruirui Zhu, Xintong Yang, Ye Feng, Qin He, Haopeng Wang, Qingyou Liu, Deshun Shi, Jieping Huang Tags: RESEARCH ARTICLE Source Type: research