miR-133a and miR-135a Regulate All-Trans Retinoic Acid-Mediated Differentiation in Pediatric Acute Myeloid Leukemia by Inhibiting CDX2 Translation and Serve as Prognostic Biomarkers

Conclusions: miR-133a and miR-135a may play an antioncogenic role in pediatric AML through the ATRA-miRNA133a/135a-CDX2 pathway. They hold promise as potentially favorable prognostic indicators and novel therapeutic targets for pediatric AML.PMID:38693824 | DOI:10.1177/15330338241248576

Source: Technology in Cancer Research and Treatment - May 2, 2024 Category: Cancer & Oncology Authors: Yu-Cai Cheng Zhong Fan Cong Liang Chun-Jin Peng Yu Li Li-Na Wang Jie-Si Luo Xiao-Li Zhang Yong Liu Li-Dan Zhang Source Type: research