Translational validity of neuropsychological tasks of sustained attention between rodents and humans: A systematic review of three rodent tasks

This study provides a systematic review that assesses the translational validity of sustained attention tasks in rodents. One hundred and thirty-eight studies were included, covering the rodent Continuous Performance Task (rCPT), Sustained Attention Task (SAT), and 5-choice CPT (5C-CPT). Translatability between rodent and human studies was assessed based on methodological similarity, performance similarity, and replication of results. The 5C-CPT was found to be the most translatable cross-species paradigm with good utility, while the rCPT and SAT require further adaptation for translation. AbstractAtypical sustained attention is a symptom in a number of neurological and psychological conditions. Investigations into its neural underpinnings are required for improved management and treatment. Rodents are useful in investigating the neurobiology underlying atypical sustained attention and several rodent tasks have been developed for use in touchscreen testing platforms that mimic methodology used in human clinical attention assessment. This systematic review was conducted to assess how translatable these rodent tasks are to equivalent clinical human tasks. Studies using the rodent Continuous Performance Task (rCPT), Sustained Attention Task (SAT), and 5-choice CPT (5C-CPT) were sought and screened. Included in the review were 138 studies, using the rCPT (n = 21), SAT (n = 90), and 5C-CPT (n = 27). Translatability between rodent and human studies was assessed based on...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: SYSTEMATIC REVIEW Source Type: research