Gastroblastoma with an ACTB-GLI1 gene fusion in a 39-year-old man

A 39-year-old man complained with intermittent reflux of acid for 6 months. Physical and laboratory tests showed no abnormalities. Gastroscopy showed a 3.0-cm submucosal mass at the gastric antrum (Fig. 1A). Ultrasound gastroscopy showed a submucosal lesion with mixed echo (Fig. 1B). Abdominal computed tomography (CT) revealed local thickening (2.7 cm in long-diameter) of the antrum wall (Fig. 1 C,D). The tumor was resected completely by endoscopic submucosal desertion (ESD). Under microscopy, the tumor was composed of mesenchymal cells which were spindle to ovoid shaped, without obvious atypia, and were arranged in a reticular or short fascicular pattern (Fig.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research