Molecules, Vol. 29, Pages 2079: The Analgesic Potential of Litsea Species: A Systematic Review

Molecules, Vol. 29, Pages 2079: The Analgesic Potential of Litsea Species: A Systematic Review Molecules doi: 10.3390/molecules29092079 Authors: May Poh Yik Goh Raudhatun Na’emah Samsul Amal Widaad Mohaimin Hui Poh Goh Nurul Hazlina Zaini Nurolaini Kifli Norhayati Ahmad Various plant species from the Litsea genus have been claimed to be beneficial for pain relief. The PRISMA approach was adopted to identify studies that reported analgesic properties of plants from the Litsea genus. Out of 450 records returned, 19 primary studies revealed the analgesic potential of nine Litsea species including (1) Litsea cubeba, (2) Litsea elliptibacea, (3) Litsea japonica, (4) Litsea glutinosa, (5) Litsea glaucescens, (6) Litsea guatemalensis, (7) Litsea lancifolia, (8) Litsea liyuyingi and (9) Litsea monopetala. Six of the species, 1, 3, 4, 7, 8 and 9, demonstrated peripheral antinociceptive properties as they inhibited acetic-acid-induced writhing in animal models. Species 1, 3, 4, 8 and 9 further showed effects via the central analgesic route at the spinal level by increasing the latencies of heat stimulated-nocifensive responses in the tail flick assay. The hot plate assay also revealed the efficacies of 4 and 9 at the supraspinal level. Species 6 was reported to ameliorate hyperalgesia induced via partial sciatic nerve ligation (PSNL). The antinociceptive effects of 1 and 3 were attributed to the regulatory effects of their bioactive compounds on inflammatory media...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research