0P24. T cells and anti-inflammatory interleukins in skin biopsies of Complex Regional Pain Syndrome (CRPS)

CRPS (Complex regional Pain Syndrome) is a neuropathic pain syndrome occurring after trauma. It is associated with increased posttraumatic inflammation. Patients show inflammatory signs like increased skin temperature, edema, hyperhidrosis, and hypertrichosis. In CRPS blood samples pro-inflammatory cytokines were increased and anti-inflammatory cytokines reduced. We found in skin biopsies an increase of pro-inflammatory cytokines (TNF-α, Il-6) and mast cells. The aim of this study was the quantification of T cells and the immunohistochemical staining of anti-inflammatory interleukins and of Interferon-γ (IFN- in the skin of CRPS patients.

Source: Clinical Neurophysiology - July 5, 2015 Category: Neuroscience Authors: T. Schlereth, S. Bolz, N. Albrecht, F. Birklein Source Type: research